2021
Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study
Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.Peer-Reviewed Original ResearchMeSH KeywordsBlood Component TransfusionCohort StudiesEnd Stage Liver DiseaseEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansPlasmaRetrospective StudiesSeverity of Illness IndexConceptsAcute variceal hemorrhageFresh frozen plasma transfusionFrozen plasma transfusionFFP transfusionLength of stayPlasma transfusionVariceal hemorrhageCohort studyClinical outcomesEnd-stage liver disease (MELD) scoreStage liver disease scoreTertiary health care centerSevere variceal bleedingLiver Disease scoreMulticentre cohort studyRetrospective cohort studyHigh-risk patientsOdds of mortalityPoor clinical outcomeHealth care centersMultivariable regression analysisEligible patientsActive bleedingVariceal bleedingMultivariable analysis
2019
Interventions for Primary Prevention of Esophageal Variceal Bleeding
Laine L. Interventions for Primary Prevention of Esophageal Variceal Bleeding. Hepatology 2019, 69: 1382-1384. PMID: 30561058, DOI: 10.1002/hep.30463.Commentaries, Editorials and LettersEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLigationNetwork Meta-AnalysisPrimary PreventionManagement of acute upper gastrointestinal bleeding
Stanley AJ, Laine L. Management of acute upper gastrointestinal bleeding. The BMJ 2019, 364: l536. PMID: 30910853, DOI: 10.1136/bmj.l536.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnti-Bacterial AgentsBlood TransfusionDisease ManagementEndoscopy, GastrointestinalEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLiver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticPractice Guidelines as TopicProton Pump InhibitorsResuscitationSeverity of Illness IndexConceptsUpper gastrointestinal bleedingProton pump inhibitorsVariceal bleedingUlcer bleedingGastrointestinal bleedingEndoscopic therapyVasoactive drugsPump inhibitorsHigh-dose proton pump inhibitorsAcute upper gastrointestinal bleedingDose proton pump inhibitorsTransjugular intrahepatic portosystemic shuntNon-variceal bleedingRecurrent ulcer bleedingRecurrent variceal bleedingRed cell transfusionCommon medical emergencyIntrahepatic portosystemic shuntEarly endoscopyCell transfusionHemodynamic instabilityHemoglobin thresholdEndoscopic treatmentIntravenous fluidsPortosystemic shunt
2018
Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis
Laine L, Laursen SB, Zakko L, Dalton HR, Ngu JH, Schultz M, Stanley AJ. Severity and Outcomes of Upper Gastrointestinal Bleeding With Bloody Vs. Coffee-Grounds Hematemesis. The American Journal Of Gastroenterology 2018, 113: 358. PMID: 29380820, DOI: 10.1038/ajg.2018.5.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood PreservationBlood TransfusionEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHeart RateHematemesisHemoglobinsHemostasis, EndoscopicHumansMaleMelenaMiddle AgedMortalityProspective StudiesRecurrenceRisk AssessmentSeverity of Illness IndexUpper Gastrointestinal TractConceptsCoffee ground emesisBloody emesisHemostatic interventionUpper gastrointestinal bleedingComposite end pointRisk stratification scoresSystolic blood pressureTiming of endoscopyPredictors of outcomeBeats/minGastrointestinal bleedingConsecutive patientsPrimary outcomeSevere bleedingStratification scoresBlood pressureProspective studyHematemesisMelenaEmesisHigh mortalityEnd pointMortalityOutcomesSeverity
2017
Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices?
Laine L. Is there a role for combined sclerotherapy and ligation in the endoscopic treatment of gastroesophageal varices? Gastrointestinal Endoscopy 2017, 86: 316-318. PMID: 28728669, DOI: 10.1016/j.gie.2017.02.005.Commentaries, Editorials and LettersMeSH KeywordsCombined Modality TherapyEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLigationRecurrenceSclerotherapyVaricose Veins
2016
Randomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding
Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L. Randomized trial of 1‐week versus 2‐week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology 2016, 64: 549-555. PMID: 27082942, PMCID: PMC4956532, DOI: 10.1002/hep.28597.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedEndoscopy, GastrointestinalEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHumansMaleMiddle AgedProspective StudiesTime FactorsTreatment OutcomeConceptsEsophageal variceal bleedingVariceal bleedingVariceal eradicationAcute esophageal variceal bleedingBeta-blocker therapyProportion of patientsTreatment of patientsNumber of endoscopiesMean numberLigation sessionsChest painPrimary endpointAdverse eventsClinical outcomesEndoscopic ligationLast endoscopyPhysician preferencePatientsBleedingSuccessful ligationEndoscopyConfidence intervalsEradicationLigationWeeks
2015
Factors impacting physicians’ decisions to prevent variceal hemorrhage
Yan K, Bridges J, Augustin S, Laine L, Garcia-Tsao G, Fraenkel L. Factors impacting physicians’ decisions to prevent variceal hemorrhage. BMC Gastroenterology 2015, 15: 55. PMID: 25934271, PMCID: PMC4423490, DOI: 10.1186/s12876-015-0287-1.Peer-Reviewed Original ResearchConceptsEndoscopic variceal ligationEradication of varicesLiver diseaseFirst variceal bleedMore daysSpecific treatment attributesLatent class analysisMechanism of actionVariceal bleedVariceal hemorrhageLarge varicesVariceal ligationPhysician characteristicsTreatment preferencesTreatment characteristicsTreatment attributesGroup 2Side effectsPrevention strategiesClass analysisVaricesPatientsPhysiciansDistinct subgroupsStandardized patients
2014
Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding
Kim JJ, Sheibani S, Park S, Buxbaum J, Laine L. Causes of Bleeding and Outcomes in Patients Hospitalized With Upper Gastrointestinal Bleeding. Journal Of Clinical Gastroenterology 2014, 48: 113-118. PMID: 23685847, DOI: 10.1097/mcg.0b013e318297fb40.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEndoscopy, GastrointestinalEsophageal and Gastric VaricesEsophagitisFemaleGastrointestinal HemorrhageHematemesisHospital MortalityHospitalizationHumansLength of StayMaleMedicaidMedicareMelenaMiddle AgedPeptic UlcerPeptic Ulcer HemorrhageRetreatmentRetrospective StudiesUnited StatesConceptsUpper gastrointestinal bleedingGastrointestinal bleedingCommon causeOutcomes of UGIBVariceal upper gastrointestinal bleedingNonvariceal upper gastrointestinal bleedingCause of bleedingRisk of deathLower socioeconomic patientsUrban US hospitalsErosive esophagitisInpatient mortalityRepeat endoscopyUpper endoscopyConsecutive patientsClinical outcomesPeptic ulcerMean ageMedical CenterUrban hospitalPatientsUS hospitalsMultivariate analysisHematemesisEndoscopy
2012
Balloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices
Dadabhai AS, Fenkel JM, Brown DB, Laine L. Balloon‐occluded retrograde transvenous obliteration for the treatment of gastric varices. Hepatology 2012, 55: 1301-1304. PMID: 22318957, DOI: 10.1002/hep.25635.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBalloon OcclusionEsophageal and Gastric VaricesHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment Outcome
2010
Primary prophylaxis of esophageal variceal bleeding: An endoscopic approach
Laine L. Primary prophylaxis of esophageal variceal bleeding: An endoscopic approach. Journal Of Hepatology 2010, 52: 944-945. PMID: 20381891, DOI: 10.1016/j.jhep.2009.12.035.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2008
Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists
ESRAILIAN E, GRALNEK IM, JENSEN D, LAINE L, DULAI GS, EISEN G, SPIEGEL BM. Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists. Alimentary Pharmacology & Therapeutics 2008, 28: 1199-1208. PMID: 18729846, DOI: 10.1111/j.1365-2036.2008.03838.x.Peer-Reviewed Original ResearchConceptsHigh-risk bleedingProcess of careIntravenous proton pump inhibitorsNonvariceal upper gastrointestinal hemorrhageUpper gastrointestinal tract hemorrhageLarge-channel endoscopeUpper gastrointestinal hemorrhageUse of hemoclipsGastrointestinal tract hemorrhageProton pump inhibitorsChoice of endoscopeNasogastric lavageGastrointestinal hemorrhageTract hemorrhagePromotility agentsContinuous infusionPump inhibitorsGuideline complianceWide variationBleedingHemorrhageGastroenterologistsVignette surveyCareEndoscopeEsophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension
de Franchis R, Eisen GM, Laine L, Fernandez‐Urien I, Herrerias JM, Brown RD, Fisher L, Vargas HE, Vargo J, Thompson J, Eliakim R. Esophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension. Hepatology 2008, 47: 1595-1603. PMID: 18435461, DOI: 10.1002/hep.22227.Peer-Reviewed Original ResearchConceptsEsophageal varicesEsophageal capsule endoscopyNegative predictive valuePositive predictive valuePredictive valueCapsule endoscopyPortal hypertensionLarge esophageal varicesVariceal gradeLarge varicesMulticenter trialCurrent guidelinesEsophagogastroduodenoscopyTreatment decisionsVaricesCapsule studyPatientsEndoscopyPilot studyDiagnostic performanceEquivalence studyKappa scoresMinimal invasivenessCirrhosisHypertension
2005
The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later
Laine LA, Nathwani RA, Naritoku W. The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later. Gastrointestinal Endoscopy 2005, 62: 853-859. PMID: 16301025, DOI: 10.1016/j.gie.2005.09.019.Peer-Reviewed Original ResearchConceptsH pylori densityAcute GI bleedingInflammatory cell infiltrationH pyloriGI bleedingHistologic examinationCohort studyCell infiltrationDiagnostic testingBlinded histologic examinationH pylori testingAcute variceal bleedingProspective cohort studyUrban county hospitalProton pump inhibitorsTime of bleedingRapid urease testingVariceal bleedingCase seriesEndoscopic biopsyProspective studyPump inhibitorsBiopsy specimensUrease testingCounty Hospital
1997
Management of actively bleeding esophageal varices
Laine L. Management of actively bleeding esophageal varices. Gastrointestinal Endoscopy 1997, 46: 83-84. PMID: 9260714, DOI: 10.1016/s0016-5107(97)70218-9.Commentaries, Editorials and Letters
1996
Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices
Laine L, Stein C, Sharma V. Randomized comparison of ligation versus ligation plus sclerotherapy in patients with bleeding esophageal varices. Gastroenterology 1996, 110: 529-533. PMID: 8566601, DOI: 10.1053/gast.1996.v110.pm8566601.Peer-Reviewed Original ResearchMeSH KeywordsAdultCombined Modality TherapyEsophageal and Gastric VaricesFemaleFollow-Up StudiesGastrointestinal HemorrhageHumansLigationMaleMiddle AgedProspective StudiesRecurrenceSclerotherapyTime FactorsConceptsEsophageal varicesVariceal eradicationCombined therapyTreatment sessionsMajor bleedingMean followEndoscopic sclerotherapyHospital daysRepeat endoscopyRandomized comparisonSclerotherapyVaricesPatientsAbstractTextTherapyMore sessionsLigationEradicationComplicationsSignificant differencesAIMSTreatmentSessionsGreater timeBleeding
1995
Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis.
Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Annals Of Internal Medicine 1995, 123: 280-7. PMID: 7611595, DOI: 10.7326/0003-4819-123-4-199508150-00007.Peer-Reviewed Original ResearchMeSH KeywordsCause of DeathEndoscopyEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansLigationOdds RatioRandomized Controlled Trials as TopicRecurrenceSclerotherapyConceptsEsophageal variceal bleedingTreatment of patientsEndoscopic ligationVariceal bleedingEsophageal varicesEndoscopic treatmentDuplicate data abstractionDuplicate independent reviewEndoscopic treatment sessionsRate of deathRelevant primary articlesReview of citationsVariceal obliterationBacterial peritonitisLigation therapyPulmonary infectionEsophageal strictureMethodologic qualitySclerotherapyMortality rateTreatment sessionsPatientsRelevant articlesPrimary investigatorUnpublished studiesLigation: Endoscopic treatment of choice for patients with bleeding esophageal varices?
Laine L. Ligation: Endoscopic treatment of choice for patients with bleeding esophageal varices? Hepatology 1995, 22: 663-665. PMID: 7635437, DOI: 10.1002/hep.1840220242.Commentaries, Editorials and LettersEsophageal and Gastric VaricesEsophagoscopyGastrointestinal HemorrhageHumansLigationRandomized Controlled Trials as Topic
1993
Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices.
Laine L, el-Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Annals Of Internal Medicine 1993, 119: 1-7. PMID: 8498757, DOI: 10.7326/0003-4819-119-1-199307010-00001.Peer-Reviewed Original ResearchMeSH KeywordsAdultEsophageal and Gastric VaricesEsophageal DiseasesEsophagoscopyFemaleGastrointestinal HemorrhageHumansLigationMaleMiddle AgedRecurrenceSclerotherapyTreatment FailureUlcerConceptsRisk of deathEsophageal varicesVariceal eradicationEndoscopic examinationLigation groupInitial endoscopic examinationUrban county hospitalKaplan-Meier estimatesLigation treatmentTransfusion requirementsVariceal obliterationFurther bleedingHospital stayEndoscopic sclerotherapyEndoscopic therapyEsophageal ulcerLocal complicationsRecurrent varicesBlood transfusionSevere bleedingEndoscopic ligationTreatment failureEsophageal strictureCounty HospitalSclerotherapy
1992
Indications, Technique, and Complications of Balloon Tamponade for Variceal Gastrointestinal Bleeding
Cook D, Laine L. Indications, Technique, and Complications of Balloon Tamponade for Variceal Gastrointestinal Bleeding. Journal Of Intensive Care Medicine 1992, 7: 212-218. PMID: 10147943, DOI: 10.1177/088506669200700408.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBalloon OcclusionCatheterizationClinical Trials as TopicEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansSclerotherapyConceptsBalloon tamponadeAcute upper gastrointestinal haemorrhageVariceal gastrointestinal bleedingUpper gastrointestinal hemorrhageBalloon insertionGastrointestinal bleedingGastrointestinal hemorrhageEsophageal varicesPotential complicationsTherapeutic endoscopyTimely treatmentTamponadeComplicationsVaricesBleedingSclerotherapyHemorrhagePatientsEndoscopyHemostatis
1990
Acute variceal bleeding: Still searching for the right treatment
Silvain C, Fort E, Ingrand P, Beauchant M, Valenzuela J, Schubert T, Posillico J, Laine L. Acute variceal bleeding: Still searching for the right treatment. Hepatology 1990, 12: 625-626. PMID: 1976106, DOI: 10.1002/hep.1840120335.Commentaries, Editorials and LettersAcute DiseaseEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansRandomized Controlled Trials as TopicSomatostatin