2002
Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough?
Laine L, Estrada R. Randomized trial of normal saline solution injection versus bipolar electrocoagulation for treatment of patients with high-risk bleeding ulcers: Is local tamponade enough? Gastrointestinal Endoscopy 2002, 55: 6-10. PMID: 11756906, DOI: 10.1067/mge.2002.120390.Peer-Reviewed Original ResearchConceptsSaline solution injectionSaline solution groupNormal saline solutionBipolar electrocoagulationLocal tamponadeNonbleeding visible vesselIndependent risk factorSolution injectionSolution groupTreatment of patientsSaline solutionMajor bleedingActive bleedingEndoscopic injectionHospital daysStandard therapyUlcer sizeLack of injuryClinical evidenceVisible vesselRisk factorsEffective treatmentPatientsBleedingUlcers
1992
Prospective evaluation of immediate versus delayed refeeding and prognostic value of endoscopy in patients with upper gastrointestinal hemorrhage
Laine L, Cohen H, Brodhead J, Cantor D, Garcia F, Mosquera M. Prospective evaluation of immediate versus delayed refeeding and prognostic value of endoscopy in patients with upper gastrointestinal hemorrhage. Gastroenterology 1992, 102: 314-316. PMID: 1727765, DOI: 10.1016/0016-5085(92)91816-m.Peer-Reviewed Original ResearchConceptsMallory-Weiss tearUpper gastrointestinal hemorrhageGastrointestinal hemorrhagePrognostic valueRegular dietMajor upper gastrointestinal hemorrhageClean-based ulcersEndoscopic evidenceHospital courseRecurrent bleedingEndoscopic findingsMajor hemorrhageClinical evidenceProspective evaluationVs. 5Entry criteriaClean baseVs. 2Lower riskPatientsUlcersUrgent interventionVs. 1HemorrhageTears
1990
Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial
Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers A prospective, randomized trial. Gastroenterology 1990, 99: 1303-1306. PMID: 2210238, DOI: 10.1016/0016-5085(90)91154-x.Peer-Reviewed Original ResearchConceptsNonbleeding visible vesselMultipolar electrocoagulationInjection therapyVisible vesselEndoscopic evidenceActive bleedingBloody nasogastric aspirateUpper gastrointestinal bleedHigh-risk patientsUnstable vital signsIncidence of surgeryTreatment of patientsCost of hospitalizationUnits of bloodFurther bleedingGastrointestinal bleedHospital stayNasogastric aspirateClinical evidencePeptic ulcerComparable efficacyMortality ratePatientsBleedingUlcers