2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2019
Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning
Johnson KM, Johnson HE, Zhao Y, Dowe DA, Staib LH. Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning. Radiology 2019, 292: 182061. PMID: 31237495, DOI: 10.1148/radiol.2019182061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansImage Interpretation, Computer-AssistedMachine LearningMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk FactorsSeverity of Illness IndexYoung AdultConceptsCoronary CT angiographyCoronary Artery Disease ReportingNonfatal myocardial infarctionHeart disease deathCT angiographyCause mortalityDisease deathsMyocardial infarctionCoronary heart disease deathDisease reportingCoronary artery diseaseNational Death IndexData System scoreCardiovascular eventsCoronary deathAdverse eventsArtery diseaseCoronary diseaseDeath IndexCoronary segmentsPrognostic informationVessel scorePatientsSystem scoreSubsequent death
2018
Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients?
Spektor M, Mathur M, Santacana G, Asch D, Huber S, Staib L, Israel G. Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients? Clinical Imaging 2018, 54: 78-83. PMID: 30562678, DOI: 10.1016/j.clinimag.2018.12.002.Peer-Reviewed Original ResearchConceptsAbdominal painCrohn's diseaseDisease patientsHigher health care costsAcute abdominal painBowel wall thickeningCrohn's disease patientsContrast-enhanced CTStrict inclusion criteriaHealth care costsModerate interobserver agreementRecent CTBowel obstructionConsecutive patientsMR enterographyPatient riskInclusion criteriaBlinded reviewAbdominal radiologistsMRE examinationsCare costsWall thickeningFree fluidRoutine useDiagnostic CT
2015
Anterior Cortical Development During Adolescence in Bipolar Disorder
Najt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.Peer-Reviewed Original ResearchConceptsWhite matter expansionBipolar disorderWhite matterAnterior cortexHealthy adolescentsHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansWhite matter increasesResonance imaging scansGray matter decreasesDorsolateral prefrontal cortexMatter expansionHealthy groupImaging scansCortical volumeFrontal cortexNeurodevelopmental abnormalitiesCortical developmentAnterior paralimbicNeurodevelopmental modelLongitudinal neuroimagingPrefrontal cortexCortexLongitudinal studyAdolescentsThe clinical impact of gynecologic MRI.
Ratner ES, Staib LH, Cross SN, Raji R, Schwartz PE, McCarthy SM. The clinical impact of gynecologic MRI. American Journal Of Roentgenology 2015, 204: 674-80. PMID: 25714302, DOI: 10.2214/ajr.14.12567.Peer-Reviewed Original ResearchConceptsPelvic MRIFirst modalityClinical managementClinical impactGynecologic massesIndeterminate pelvic massesGroup of patientsResults of MRIRadiologic recordsRadiologic findingsPelvic massClinical recordsUnnecessary surgeryMedical recordsCT examinationsFurther endpointsExact diagnosisPatientsSurgeryIndeterminate massesPatient treatmentMRIDiagnosisModalitiesResultant anxietyUtility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions
Macer ML, Mathur M, Spektor M, Gysler S, Staib L, Kodaman P, McCarthy S. Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions. Journal Of Computer Assisted Tomography 2015, 39: 896-900. PMID: 26466105, DOI: 10.1097/rct.0000000000000302.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPelvic adhesionsPositive predictive valuePredictive valueResonance imagingSpecificity of MRIGynecologic abdominal surgeryInstitutional review board-approved retrospective analysisNegative predictive valueAnterior culPosterior culAbdominal surgeryOperative reportsInclusion criteriaRetrospective analysisStudy populationBlinded specialistsMRI sensitivityPatientsImaging
2014
Using SUV as a Guide to 18F-FDG Dose Reduction
Cheng DW, Ersahin D, Staib LH, Della Latta D, Giorgetti A, d’Errico F. Using SUV as a Guide to 18F-FDG Dose Reduction. Journal Of Nuclear Medicine 2014, 55: 1998-2002. PMID: 25453048, DOI: 10.2967/jnumed.114.140129.Peer-Reviewed Original Research
2011
Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder
Edmiston EE, Wang F, Kalmar JH, Womer FY, Chepenik LG, Pittman B, Gueorguieva R, Hur E, Spencer L, Staib LH, Constable RT, Fulbright RK, Papademetris X, Blumberg HP. Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder. Psychiatry Research 2011, 194: 400-402. PMID: 22041535, PMCID: PMC3225709, DOI: 10.1016/j.pscychresns.2011.07.005.Peer-Reviewed Original Research
2009
Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes