2024
Reliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology
Zeevi T, Leapman M, Sprenkle P, Venkataraman R, Staib L, Onofrey J. Reliable Prostate Cancer Risk Mapping From MRI Using Targeted and Systematic Core Needle Biopsy Histopathology. IEEE Transactions On Biomedical Engineering 2024, 71: 1084-1091. PMID: 37874731, PMCID: PMC10901528, DOI: 10.1109/tbme.2023.3326799.Peer-Reviewed Original ResearchMagnetic resonance imagingIndividual patientsBiopsy locationProstate biopsy dataBiopsy histopathologyHistopathology scoresPathology scoresBiopsy dataMRI biomarkersTreatment planPatientsResonance imagingProstate regionBiomarkersTherapy treatment plansPathologyRepresentative sampleScoresImaging analysisPrevious studiesHistopathologyProstateCancerClinicians
2023
Deferral of Estimated Glomerular Filtration Rate Testing Before Contrast-Enhanced CT in Low-Risk Emergency Department Patients: Assessment of Safety and Impact on Throughput
Gunabushanam G, Asch D, van Luling J, Kuehne A, Alkukhun A, Staib L, Venkatesh A, Pahade J. Deferral of Estimated Glomerular Filtration Rate Testing Before Contrast-Enhanced CT in Low-Risk Emergency Department Patients: Assessment of Safety and Impact on Throughput. Journal Of The American College Of Radiology 2023, 21: 52-60. PMID: 37939813, DOI: 10.1016/j.jacr.2023.11.003.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseContrast-enhanced CTLower riskED providersMedian OSEGFR testingContrast-induced acute kidney injuryLow-risk emergency department patientsLow-risk ED patientsProportion of patientsEmergency department patientsClinical risk assessmentGlomerular filtration rate testingAssessment of safetyChronic dialysisKidney injuryDepartment patientsED patientsEGFR valuesKidney diseaseRisk factorsPatientsCECT studiesRiskA Multiclass Radiomics Method–Based WHO Severity Scale for Improving COVID-19 Patient Assessment and Disease Characterization From CT Scans
Henao J, Depotter A, Bower D, Bajercius H, Todorova P, Saint-James H, de Mortanges A, Barroso M, He J, Yang J, You C, Staib L, Gange C, Ledda R, Caminiti C, Silva M, Cortopassi I, Dela Cruz C, Hautz W, Bonel H, Sverzellati N, Duncan J, Reyes M, Poellinger A. A Multiclass Radiomics Method–Based WHO Severity Scale for Improving COVID-19 Patient Assessment and Disease Characterization From CT Scans. Investigative Radiology 2023, 58: 882-893. PMID: 37493348, PMCID: PMC10662611, DOI: 10.1097/rli.0000000000001005.Peer-Reviewed Original ResearchConceptsCOVID-19 positive patientsClinical Progression ScaleLung lesionsLesion modelDisease severityGround-glass opacitiesCOVID-19 patientsRadiologist assessmentExpert thoracic radiologistsMulticenter cohortPleural effusionDisease extentRetrospective studyDevelopment cohortPatient assessmentTomography scanCT scanSeverity ScalePatient's diseaseTissue lesionsThoracic radiologistsLesionsPatientsRadiomics modelRadiomic features
2021
Voiding and Storage Domain-Specific Symptom Score Outcomes After Prostate Artery Embolization for Lower Urinary Tract Symptoms and Urinary Retention
Powell T, Staib L, Liu B, Bhatia S, Chai T, Ayyagari R. Voiding and Storage Domain-Specific Symptom Score Outcomes After Prostate Artery Embolization for Lower Urinary Tract Symptoms and Urinary Retention. Urology 2021, 156: 216-224. PMID: 33961894, DOI: 10.1016/j.urology.2021.02.046.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsProstate artery embolizationBenign prostatic hyperplasiaUrinary tract symptomsLUTS patientsIPSS-VUrinary retentionRetention patientsArtery embolizationTract symptomsTotal International Prostate Symptom ScoreDomain scoresInternational Prostate Symptom ScoreComponent scoresProstate Symptom ScoreSingle centerSymptom scoresLife scoresProstatic hyperplasiaIPSSPatientsPre-PAEQoLMonthsScore outcomes
2020
Creating a Radiology Call Center Hotline and “HOT” Sites: Centralizing Radiology Questions and Cohorting Out-patient Care During the COVID-19 Pandemic
Jang B, Facchini D, Staib L, Fernandez A, Pye S, Goodman RT, Granucci C, Nardecchia N, Pahade JK. Creating a Radiology Call Center Hotline and “HOT” Sites: Centralizing Radiology Questions and Cohorting Out-patient Care During the COVID-19 Pandemic. Current Problems In Diagnostic Radiology 2020, 50: 665-668. PMID: 33036812, PMCID: PMC7519410, DOI: 10.1067/j.cpradiol.2020.09.018.Peer-Reviewed Original ResearchConceptsPatient encountersMost common reasonsCOVID-19 symptomsOut-patient careCOVID-19High-quality patientDate of studyCOVID-19 screeningQuality patientCOVID-19 transmissionX-ray examsCommon reasonRadiology technologistsPatientsCOVID-19 pandemicTime of examImaging sitesCareRadiology operationsExamTotal
2019
Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning
Johnson KM, Johnson HE, Zhao Y, Dowe DA, Staib LH. Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning. Radiology 2019, 292: 182061. PMID: 31237495, DOI: 10.1148/radiol.2019182061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansImage Interpretation, Computer-AssistedMachine LearningMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk FactorsSeverity of Illness IndexYoung AdultConceptsCoronary CT angiographyCoronary Artery Disease ReportingNonfatal myocardial infarctionHeart disease deathCT angiographyCause mortalityDisease deathsMyocardial infarctionCoronary heart disease deathDisease reportingCoronary artery diseaseNational Death IndexData System scoreCardiovascular eventsCoronary deathAdverse eventsArtery diseaseCoronary diseaseDeath IndexCoronary segmentsPrognostic informationVessel scorePatientsSystem scoreSubsequent death
2017
(Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry
Zaveri H, Ganesh N, Goncharova I, Damisah E, Ong C, Perez E, Staib L, Hirsch L, Petroff O, Spencer D, Eid T. (Invited) Conjoint Measurement of Brain Electrophysiology and Neurochemistry. ECS Meeting Abstracts 2017, MA2017-02: 2329-2329. DOI: 10.1149/ma2017-02/55/2329.Peer-Reviewed Original ResearchInterictal EEG spikesBasal glutamateBrain excitabilityIntractable epilepsyEEG spikesBrain electrophysiologySpike rateBasal extracellular glutamate concentrationsIntracranial EEG monitoringExtracellular glutamate concentrationCo-localized measurementsPossible epilepsy surgeryBrain extracellular glutamateInterictal electroencephalographyMicrodialysis catheterEpilepsy surgeryExtracellular glutamateBrain neurochemistryDialysis probeNeurochemical basisEEG monitoringGlutamate concentrationBrain regionsEpilepsyPatients
2016
Knowledge of Density and Screening Ultrasound
Moothathu NS, Philpotts LE, Busch SH, Gross CP, Staib LH, Hooley RJ. Knowledge of Density and Screening Ultrasound. The Breast Journal 2016, 23: 323-332. PMID: 27943500, DOI: 10.1111/tbj.12734.Peer-Reviewed Original ResearchConceptsBreast density awarenessBreast densityDense breast tissueScreening ultrasoundBreast cancerCaucasian raceBreast tissueBreast ultrasoundSupplemental breast ultrasoundBreast cancer riskBreast density notification lawsNon-Caucasian patientsPercent of participantsPhysician recommendationProvider recommendationAcademic breastSelf-administered surveyUltrasoundWomenPatientsCancerMammography reportsTissueAnxietyHigher income
2015
The clinical impact of gynecologic MRI.
Ratner ES, Staib LH, Cross SN, Raji R, Schwartz PE, McCarthy SM. The clinical impact of gynecologic MRI. American Journal Of Roentgenology 2015, 204: 674-80. PMID: 25714302, DOI: 10.2214/ajr.14.12567.Peer-Reviewed Original ResearchConceptsPelvic MRIFirst modalityClinical managementClinical impactGynecologic massesIndeterminate pelvic massesGroup of patientsResults of MRIRadiologic recordsRadiologic findingsPelvic massClinical recordsUnnecessary surgeryMedical recordsCT examinationsFurther endpointsExact diagnosisPatientsSurgeryIndeterminate massesPatient treatmentMRIDiagnosisModalitiesResultant anxietyUtility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions
Macer ML, Mathur M, Spektor M, Gysler S, Staib L, Kodaman P, McCarthy S. Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions. Journal Of Computer Assisted Tomography 2015, 39: 896-900. PMID: 26466105, DOI: 10.1097/rct.0000000000000302.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPelvic adhesionsPositive predictive valuePredictive valueResonance imagingSpecificity of MRIGynecologic abdominal surgeryInstitutional review board-approved retrospective analysisNegative predictive valueAnterior culPosterior culAbdominal surgeryOperative reportsInclusion criteriaRetrospective analysisStudy populationBlinded specialistsMRI sensitivityPatientsImaging
2012
Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma
Silva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.Peer-Reviewed Original ResearchConceptsPediatric extremity traumaExtremity traumaSite of painPediatric emergency departmentSite of injuryPain sitesEmergency departmentLimb traumaContralateral limbExtremity radiographsFracture sitePatientsFurther evaluationRadiographsTraumaSame dayEarly assessmentWhole limbIntellectual disabilityLocal hyperthermiaYoung childrenDITIEfficacyLimbFractures
2011
SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY
Tandon S, Bansal S, Inzucchi S, Staib L, Davey J, Chyun D, Young L, Wackers F. SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY. Journal Of The American College Of Cardiology 2011, 57: e745. DOI: 10.1016/s0735-1097(11)60745-6.Peer-Reviewed Original Research
2008
A Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy
Greene W, Chelikani S, Purushothaman K, Chen Z, Knisely J, Staib L, Papademetris X, Duncan J. A Constrained Non-rigid Registration Algorithm for Use in Prostate Image-Guided Radiotherapy. Lecture Notes In Computer Science 2008, 11: 780-788. PMID: 18979817, PMCID: PMC2790815, DOI: 10.1007/978-3-540-85988-8_93.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceHumansImaging, Three-DimensionalMalePattern Recognition, AutomatedProstatic NeoplasmsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiotherapy, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray ComputedConceptsTreatment planProstate image-guided radiotherapyOriginal treatment planRadiation dosageImage-guided radiotherapyTreatment daysRadiotherapy treatment plansCritical organsDifferent patientsPatient dataDifferent treatment daysBladderRectumProstateFemurBone motionCT imagesDosageReal patient dataPatientsRadiotherapy
2002
Reduced volume of orbitofrontal cortex in major depression
Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry 2002, 51: 273-279. PMID: 11958777, DOI: 10.1016/s0006-3223(01)01336-1.Peer-Reviewed Original ResearchConceptsMajor depressionOrbitofrontal cortexOrbitofrontal cortical volumeCortical volumeArea 32Area 24Brodmann's area 32Recent postmortem studiesWhole brain volumeSymptoms of depressionBrodmann's area 24Magnetic resonance imagingFrontal cortical regionsFunctional neuroimaging studiesSubcallosal gyrusDepressed patientsPostmortem studiesCortical subregionsComparison subjectsBrain volumePatientsResonance imagingCortical regionsCortexNeuroimaging studies
2000
Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study
Vythilingam M, Anderson E, Goddard A, Woods S, Staib L, Charney D, Bremner J. Temporal lobe volume in panic disorder — a quantitative magnetic resonance imaging study. Psychiatry Research 2000, 99: 75-82. PMID: 10963983, DOI: 10.1016/s0925-4927(00)00055-x.Peer-Reviewed Original ResearchConceptsTemporal lobe volumePanic disorderTemporal lobeMagnetic resonance imagingControl subjectsHealthy subjectsLobe volumeSmaller temporal lobe volumeNormal hippocampal volumesMagnetic resonance imaging studyHealthy control subjectsRight temporal lobeQuantitative magnetic resonance imaging studyQuantitative MRI measuresWhole brain volumeResonance imaging studyHippocampal volumeBrain changesMRI measuresBrain volumeWhole brainPatientsQualitative abnormalitiesResonance imagingImaging studiesDecreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mappingHippocampal Volume Reduction in Major Depression
Bremner J, Narayan M, Anderson E, Staib L, Miller H, Charney D. Hippocampal Volume Reduction in Major Depression. American Journal Of Psychiatry 2000, 157: 115-118. PMID: 10618023, DOI: 10.1176/ajp.157.1.115.Peer-Reviewed Original ResearchConceptsSmaller left hippocampal volumeLeft hippocampal volumeHippocampal volumeMajor depressionComparison subjectsHippocampal volume reductionWhole brain volumeMagnetic resonance imagingNondepressed comparison subjectsAlcohol exposureBrain areasBrain volumeResonance imagingPatientsElevated levelsDepressionHippocampusVolume reductionComparison regionBrain sizeSubjectsRemissionGlucocorticoidsFindingsSPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decrease
1997
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse
Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse. JAMA Psychiatry 1997, 54: 364-374. PMID: 9107153, DOI: 10.1001/archpsyc.1997.01830160092012.Peer-Reviewed Original ResearchConceptsCerebral metabolic correlatesDepressive relapseBrain metabolismMajor depressionMiddle frontal gyrusOrbitofrontal cortexTryptophan depletionMetabolic correlatesPositron emission tomography scanningFrontal gyrusRelapse-prone patientsPathogenesis of depressionPositron emission tomography (PET) measurementsSerotonin reuptake inhibitorsSymptoms of patientsPositron emission tomographySingle photon emissionSpecific brain regionsDorsolateral prefrontal cortexReuptake inhibitorsPlasma tryptophanLimbic regionsCaudate nucleusDepressive symptomsPatientsPositron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortex