2024
Monte-Carlo Frequency Dropout for Predictive Uncertainty Estimation in Deep Learning
Zeevi T, Venkataraman R, Staib L, Onofrey J. Monte-Carlo Frequency Dropout for Predictive Uncertainty Estimation in Deep Learning. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635511.Peer-Reviewed Original ResearchArtificial neural networkState-of-the-artMedical image dataPredictive uncertainty estimationBiomedical image dataImage dataOptimal artificial neural networkMC dropoutDropout approachSource-codeDrop-connectDeep learningNeural networkSignal spaceMonte-CarloPrediction uncertaintyUncertainty estimationDiverse setComprehensive comparisonPrediction scenariosDeepPosterior predictive distributionRepositoryDecision-makingNetworkIn vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjectsChapter 20 Motion and deformation recovery and analysis
Duncan J, Staib L. Chapter 20 Motion and deformation recovery and analysis. 2024, 519-548. DOI: 10.1016/b978-0-12-813657-7.00033-9.Peer-Reviewed Original ResearchArtificial neural networkData-driven approachDeep learningMedical imagesOptical flow methodMotion estimationNeural networkDense flow fieldLocal informationShape trackingFeature trackingAlgorithm performanceMedical imagingExample applicationUse of modelsDeformation recoveryFlow fieldTrackingDeformation analysisKalman filteringMotion analysisBiomechanical deformationFlow methodDeformationEvaluation approachChapter 13 Data-driven learning strategies for biomarker detection and outcome prediction in Autism from task-based fMRI
Duncan J, Staib L, Dvornek N, Li X, Zhuang J, Wang J, Ventola P. Chapter 13 Data-driven learning strategies for biomarker detection and outcome prediction in Autism from task-based fMRI. 2024, 357-393. DOI: 10.1016/b978-0-32-385124-4.00024-6.Peer-Reviewed Original ResearchLong short-term memoryGraph neural networksFunctional magnetic resonance imagingAutism spectrum disorderNeural ordinary differential equationsData-driven learning strategyDeep learning techniquesTask-based functional magnetic resonance imagingShort-term memoryNeural networkLearning techniquesImpaired social interactionTerm memoryBehavioral therapyRepetitive behaviorsSpectrum disorderDevelopmental disordersLearning strategiesSpatio-temporal characteristicsInherent dynamicsCharacterization of individualsModel of causalitySocial interactionNetworkPersonalized outcome predictions
2023
Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning
Kucukkaya A, Zeevi T, Chai N, Raju R, Haider S, Elbanan M, Petukhova-Greenstein A, Lin M, Onofrey J, Nowak M, Cooper K, Thomas E, Santana J, Gebauer B, Mulligan D, Staib L, Batra R, Chapiro J. Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning. Scientific Reports 2023, 13: 7579. PMID: 37165035, PMCID: PMC10172370, DOI: 10.1038/s41598-023-34439-7.Peer-Reviewed Original Research
2022
Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis
Bahar RC, Merkaj S, Petersen G, Tillmanns N, Subramanian H, Brim WR, Zeevi T, Staib L, Kazarian E, Lin M, Bousabarah K, Huttner AJ, Pala A, Payabvash S, Ivanidze J, Cui J, Malhotra A, Aboian MS. Machine Learning Models for Classifying High- and Low-Grade Gliomas: A Systematic Review and Quality of Reporting Analysis. Frontiers In Oncology 2022, 12: 856231. PMID: 35530302, PMCID: PMC9076130, DOI: 10.3389/fonc.2022.856231.Peer-Reviewed Original ResearchMachine learning modelsLearning modelConvolutional neural networkDeep learning studiesLarge training datasetsGrade predictionSupport vector machineApplication of MLNeural networkConventional machineVector machineTraining datasetBest performing modelCommon algorithmsModel performanceEssential metricMean prediction accuracyHigh predictive accuracyPrediction accuracyPerforming modelMachinePrediction modelDiagnosis statementsAccuracy statementsLearning studies
2021
BrainGNN: Interpretable Brain Graph Neural Network for fMRI Analysis
Li X, Zhou Y, Dvornek N, Zhang M, Gao S, Zhuang J, Scheinost D, Staib LH, Ventola P, Duncan JS. BrainGNN: Interpretable Brain Graph Neural Network for fMRI Analysis. Medical Image Analysis 2021, 74: 102233. PMID: 34655865, PMCID: PMC9916535, DOI: 10.1016/j.media.2021.102233.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagesGraph neural network frameworkMedical image analysisGraph neural networkGraph convolutional layersNeural network frameworkDifferent evaluation metricsSpecific task statesIndependent fMRI datasetsPooling layerConvolutional layersConsistency lossNetwork frameworkNeural networkFMRI datasetsImage analysis methodEvaluation metricsDetection resultsBrain graphsSubjects releaseROI selectionImage analysisCognitive stimuliTask statesFMRI analysis
2020
Automated detection and delineation of hepatocellular carcinoma on multiphasic contrast-enhanced MRI using deep learning
Bousabarah K, Letzen B, Tefera J, Savic L, Schobert I, Schlachter T, Staib LH, Kocher M, Chapiro J, Lin M. Automated detection and delineation of hepatocellular carcinoma on multiphasic contrast-enhanced MRI using deep learning. Abdominal Radiology 2020, 46: 216-225. PMID: 32500237, PMCID: PMC7714704, DOI: 10.1007/s00261-020-02604-5.Peer-Reviewed Original ResearchConceptsDeep convolutional neural networkAverage false positive rateDice similarity coefficientU-NetDeep learning algorithmsConvolutional neural networkTest setMean Dice similarity coefficientRandom forest classifierDCNN methodDCNN approachDeep learningNet architectureLearning algorithmNeural networkLiver segmentationManual 3D segmentationForest classifierGround truthManual segmentationFalse positive rateCorresponding segmentationSegmentationMultiphasic contrast-enhanced MRIThresholding
2019
Generalizable Multi-Site Training and Testing Of Deep Neural Networks Using Image Normalization
Onofrey JA, Casetti-Dinescu DI, Lauritzen AD, Sarkar S, Venkataraman R, Fan RE, Sonn GA, Sprenkle PC, Staib LH, Papademetris X. Generalizable Multi-Site Training and Testing Of Deep Neural Networks Using Image Normalization. 2011 IEEE International Symposium On Biomedical Imaging: From Nano To Macro 2019, 00: 348-351. PMID: 32874427, PMCID: PMC7457546, DOI: 10.1109/isbi.2019.8759295.Peer-Reviewed Original ResearchDeep neural networksNeural networkDeep learning algorithmsProstate gland segmentationImage normalization methodGland segmentationLearning algorithmImage normalizationMulti-site dataIntensity normalization methodNormalization methodSingle-site dataAlgorithmNetworkPotential solutionsEquipment sourcesClinical adoptionSegmentationTrainingIntensity characteristicsRobustnessDataSite trainingMethodAdoption
2018
2-Channel Convolutional 3D Deep Neural Network (2CC3D) for FMRI Analysis: ASD Classification and Feature Learning
Li X, Dvornek NC, Papademetris X, Zhuang J, Staib LH, Ventola P, Duncan JS. 2-Channel Convolutional 3D Deep Neural Network (2CC3D) for FMRI Analysis: ASD Classification and Feature Learning. 2011 IEEE International Symposium On Biomedical Imaging: From Nano To Macro 2018, 2018: 1252-1255. PMID: 32983370, PMCID: PMC7519578, DOI: 10.1109/isbi.2018.8363798.Peer-Reviewed Original ResearchConvolutional neural networkNeural networkCNN convolutional layerSpatial featuresASD classificationDeep neural networksMean F-scoreTraditional machineFeature learningConvolutional layersInput formatF-scoreClassification modelTemporal informationNetworkWindow parametersImagesClassificationConvolutionalTemporal statisticsMachineLearningFeaturesFormatScheme