2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2023
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACE
2022
Myocardial Suppression Protocols
Osborne M, Mezue K, Divakaran S. Myocardial Suppression Protocols. 2022, 47-54. DOI: 10.1007/978-3-031-09807-9_4.Peer-Reviewed Original ResearchTreatment of inflammatory cardiovascular diseasesPatient preparation strategiesMyocardial glucose metabolismInflammatory cardiovascular diseasesPositron emission tomographyImaging techniquesInflammatory cellsPatient populationConsensus recommendationsPathological inflammationPatient preparationPharmacological interventionsEmission tomographyCardiovascular diseaseNormal myocardiumPatientsGlucose metabolismMyocardiumMetabolismInflammationDiagnosisTomographyGenetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events
Abohashem S, Osborne M, Choi K, Liu Z, Zureigat H, Mezue K, Gharios C, Armstrong K, Smoller J, Tawakol A. Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events. European Heart Journal 2022, 43: ehac544.2265. DOI: 10.1093/eurheartj/ehac544.2265.Peer-Reviewed Original ResearchLow socioeconomic statusArea Deprivation IndexSocioeconomic statusMajor adverse cardiovascular eventsRisk associated with low socioeconomic statusCardiovascular diseaseMass General Brigham BiobankPolygenic risk scoresYears of follow-upAssociation with incident major adverse cardiovascular eventsIncident major adverse cardiovascular eventsDeprivation indexHome addressAssociated with major adverse cardiovascular eventsMedian incomeRisk scoreRisk factorsMediation analysisAdverse cardiovascular eventsNeural pathwaysFunding sourcesFollow-upCardiovascular eventsStress sensitivityIndividualsThe combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYears
2021
Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection.
Egbuche O, Jegede O, Abe T, Wagle B, Huynh K, Hayes D, Campbell M, Mezue K, Ram P, Nwokike S, Desai R, Effoe V, Kpodonu J, Morgan J, Ofili E, Onwuanyi A, Echols M. Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection. Am J Cardiovasc Dis 2021, 11: 212-221. PMID: 34084656, PMCID: PMC8166582.Peer-Reviewed Original ResearchIn-hospital cardiac eventsPre-existing cardiovascular diseaseAcute kidney injuryIn-hospital mortalityAcute respiratory distress syndromeAssociated with increased oddsCardiac eventsCOVID-19 patientsKidney injuryPresence of acute kidney injuryAssociated with increased odds of in-hospital mortalityPolymerase-chain-reaction assayHigher risk of in-hospital mortalityIn-hospital acute kidney injuryAssociated with worse outcomesRisk of in-hospital mortalityCardiovascular diseaseHospitalized COVID-19 patientsRespiratory distress syndromeOdds of in-hospital mortalityAssociated with higher riskRetrospective cohort studyMortality of COVID-19 patientsIn-hospital mortality of COVID-19 patientsDistress syndromeSocial determinants and cardiovascular care: A focus on vulnerable populations and the Jamaica experience
Madu E, Mezue K, Madu K. Social determinants and cardiovascular care: A focus on vulnerable populations and the Jamaica experience. FASEB BioAdvances 2021, 3: 266-274. PMID: 33842851, PMCID: PMC8019262, DOI: 10.1096/fba.2020-00116.Peer-Reviewed Original ResearchSocial determinants of healthVulnerable populationsSocial determinantsConcept of social determinants of healthCardiovascular diseaseMedical careDeterminants of healthHigh-quality careCardiovascular disease careAt-risk populationsSDoH dataHealth inequalitiesHealthcare needsHealth outcomesCardiovascular careInfluence healthSocioeconomic statusEmployment statusCardiovascular servicesCareHealthAccess gapWork environmentBehavioral barriersPhysical environment
2020
COVID‐19 and the heart: An update for clinicians
Goha A, Mezue K, Edwards P, Nunura F, Baugh D, Madu E. COVID‐19 and the heart: An update for clinicians. Clinical Cardiology 2020, 43: 1216-1222. PMID: 32533585, PMCID: PMC7323229, DOI: 10.1002/clc.23406.Peer-Reviewed Original ResearchConceptsPrognosis of COVID-19 diseaseAdverse cardiac effectsPre-existing cardiovascular diseaseOptimal patient managementAcute myocardial injuryRisk of morbidityAcute coronary syndromeManifestations of COVID-19Cardiovascular manifestations of COVID-19Cardiovascular manifestationsCardiac effectsEffects of medicationVenous thromboembolismCoronary syndromeHeart failureMyocardial injuryPatient managementRAA systemClinical syndromeCardiovascular diseaseViral entrySARS-CoV-2COVID-19 diseaseHeartCOVID-19
2013
The increasing burden of hypertension in Nigeria – can a dietary salt reduction strategy change the trend?
Mezue K. The increasing burden of hypertension in Nigeria – can a dietary salt reduction strategy change the trend? Perspectives In Public Health 2013, 134: 346-352. PMID: 24002906, DOI: 10.1177/1757913913499658.Peer-Reviewed Original ResearchConceptsBurden of hypertensionIncreasing burden of hypertensionNon-communicable diseasesSalt reductionMiddle-income countriesPrevalence of hypertensionSalt reduction strategiesPopulation-wide basisPopulation-wide levelIncreasing burdenCardiovascular diseaseHypertensionReduction strategiesDeveloping countriesMortality