2024
The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states
Vohs J, Srihari V, Vinson A, Lapidos A, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Breier A. The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states. Learning Health Systems 2024 DOI: 10.1002/lrh2.10471.Peer-Reviewed Original ResearchEarly Psychosis Intervention NetworkIntervention NetworkFirst-episode psychosisRegional clinical networksLearning health systemQuality improvement projectQuality improvement effortsCulture of continuous learningData elementsPrimary diagnosis of schizophreniaConsecutive 6-month intervalsFirst-episode psychosis clinicUsual careSuperior patient outcomesSpecialty servicesHealth systemClinical teamImplementation meetingsQuality assurance effortsImprovement projectClinical networksHealthcare systemPractice-based researchImprovement effortsQuality improvementTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolAccelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Wannan C, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker J, Bearden C, Billah T, Bouix S, Broome M, Buccilli K, Cadenhead K, Calkins M, Cannon T, Cecci G, Chen E, Cho K, Choi J, Clark S, Coleman M, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Dwyer D, Ebdrup B, Ellman L, Fusar-Poli P, Galindo L, Gaspar P, Gerber C, Glenthøj L, Glynn R, Harms M, Horton L, Kahn R, Kambeitz J, Kambeitz-Ilankovic L, Kane J, Kapur T, Keshavan M, Kim S, Koutsouleris N, Kubicki M, Kwon J, Langbein K, Lewandowski K, Light G, Mamah D, Marcy P, Mathalon D, McGorry P, Mittal V, Nordentoft M, Nunez A, Pasternak O, Pearlson G, Perez J, Perkins D, Powers A, Roalf D, Sabb F, Schiffman J, Shah J, Smesny S, Spark J, Stone W, Strauss G, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum I, Wolf D, Wolff P, Wood S, Yung A, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrión R, Castro E, Cetin-Karayumak S, Chakravarty M, Cho Y, Cotter D, D’Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur R, Gur R, Hamilton H, Hoftman G, Jacobs G, Jarcho J, Ji J, Kohler C, Lalousis P, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas S, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt D, Rabin R, Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari V, Srivastava A, Thompson A, Turetsky B, Walsh B, Whitford T, Wigman J, Yao B, Yuen H, Ahmed U, Byun A, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek S, Bates K, Bathery A, Bayer J, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi R, Chen J, Cheng N, Ching A, Clifford C, Colton B, Contreras P, Corral S, Damiani S, Done M, Estradé A, Etuka B, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui C, Suen Y, Wong S, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Fariña G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods S, Shenton M. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, 50: 496-512. PMID: 38451304, PMCID: PMC11059785, DOI: 10.1093/schbul/sbae011.Peer-Reviewed Original ResearchClinical high-risk individualsClinical high riskNational Institute of Mental HealthInstitute of Mental HealthAttenuated positive symptomsPersistent negative symptomsTransition to psychosisCHR statusHigh riskNegative symptomsPositive symptomsAnxiety symptomsPsychosocial functioningCognitive dataOutcomes of individualsDigital health technologiesDaily surveysPsychosisSCZPublic health needsMental healthNovel pharmacological interventionsSchizophreniaClinical outcomesHealth needsAdopting a Novel Approach to Prevent and Address Patient Mistreatment of Staff in a Community Mental Health Center
Steiner J, Belisle N, Cahill J, Garcia-Vassallo G, Johnson A, Lukens C, Oliva M, Pedersen K, Shetler D, Wassmer K, Wilkins K. Adopting a Novel Approach to Prevent and Address Patient Mistreatment of Staff in a Community Mental Health Center. Psychiatric Services 2024, 75: 492-495. PMID: 38291887, DOI: 10.1176/appi.ps.20230234.Peer-Reviewed Original ResearchCommunity mental health centerMental health centerHealth centersVerbal mistreatmentCulture of safetyHealth care settingsPerformance improvement programCare settingsStaff membersPsychological impactStaffWell-beingClinical practiceImprovement programsAffective well-beingMistreatmentTrainingHealthCenterAddressConnecticutInitiationSupportProgramPractice
2022
Promoting the Success and Sustainability of Coordinated Specialty Care Teams in Ohio
Breitborde N, Parris C, Stearns W, Nawaz S, Seiber E, Hamilton S, Hefner J, Hogan T, Singh P, Knudsen K, Martt N, Srihari V, Cahill J, Jani A, Anagbonu F, Baughman C, Carpenter K, Dunivant C, Dunlap N, Guirgis H, Lazarus S, Moe A, Nguyen C, Wastler H, Montesano V. Promoting the Success and Sustainability of Coordinated Specialty Care Teams in Ohio. Psychiatric Services 2022, 74: 766-769. PMID: 36415991, DOI: 10.1176/appi.ps.20220126.Peer-Reviewed Original Research
2017
Psychopharmacology Prescribing Workshops: A Novel Method for Teaching Psychiatry Residents How to Talk to Patients About Medications
Kavanagh EP, Cahill J, Arbuckle MR, Lenet AE, Subramanyam K, Winchel RM, Nossel I, DeSilva R, Caravella RA, Ackerman M, Park HC, Ross DA. Psychopharmacology Prescribing Workshops: A Novel Method for Teaching Psychiatry Residents How to Talk to Patients About Medications. Academic Psychiatry 2017, 41: 491-496. PMID: 28194682, DOI: 10.1007/s40596-017-0662-z.Peer-Reviewed Original ResearchConceptsTwo-institutionClasses of medicationsSubset of residentsThird-year psychiatry residentsMedicationsClinical experiencePsychiatry residentsFacilitated group discussionPrescribing skillsInformed consentPatientsResultsThe courseSelf-assessment measuresResident comfortPost surveyCourseResidentsExperienced faculty membersPrescribingGroup discussions
2016
A Prescription for “Deprescribing” in Psychiatry
Gupta S, Cahill JD. A Prescription for “Deprescribing” in Psychiatry. Psychiatric Services 2016, 67: 904-907. PMID: 26975524, DOI: 10.1176/appi.ps.201500359.Peer-Reviewed Original ResearchConceptsLong-term adverse effectsRate of polypharmacyCessation of medicationIdentification of medicationsMeaning of medicationsStrong therapeutic allianceRegimen optimizationSpecific indicationsMedicationsGeriatric medicineAdverse effectsTherapeutic allianceAppropriate timingPatientsPsychiatryDeprescribingPolypharmacyRegimenReviewCaregiversCessation
2015
The Psychosis-like Effects of Δ9-Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans
Cortes-Briones JA, Cahill JD, Skosnik PD, Mathalon DH, Williams A, Sewell RA, Roach BJ, Ford JM, Ranganathan M, D’Souza D. The Psychosis-like Effects of Δ9-Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans. Biological Psychiatry 2015, 78: 805-813. PMID: 25913109, PMCID: PMC4627857, DOI: 10.1016/j.biopsych.2015.03.023.Peer-Reviewed Original ResearchConceptsPsychosis-like effectsPsychosis-like symptomsPsychotomimetic effectsNegative-like symptomsActive drug conditionsNeural noiseDose-related effectsDose-related mannerRandom neural activityDose-dependent mannerPrincipal active constituentHealthy humansPsychotic disordersCortical noiseDrug conditionsSymptomsΔ9-tetrahydrocannabinolBaseline periodDisorganization symptomsNeural activityCounterbalanced designTest dayActive constituentsOddball taskTHC
2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study
Srihari VH, Tek C, Pollard J, Zimmet S, Keat J, Cahill JD, Kucukgoncu S, Walsh BC, Li F, Gueorguieva R, Levine N, Mesholam-Gately RI, Friedman-Yakoobian M, Seidman LJ, Keshavan MS, McGlashan TH, Woods SW. Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study. BMC Psychiatry 2014, 14: 335. PMID: 25471062, PMCID: PMC4262386, DOI: 10.1186/s12888-014-0335-3.Peer-Reviewed Original ResearchConceptsEarly detectionEarly outcomesGeographic catchmentTIPS studyYounger patientsAppropriate patientsUntreated psychosisPsychosis onsetEffective treatmentCare providersPsychotic symptomsPublic education campaignsPsychotic disordersHelp-seeking behaviorSecondary aimComprehensive interventionPatientsIntervention servicesDUPEducation campaignsOutcomesSocial marketing approachPrimary aimTreatmentFESTesting differences in the activity of event-related potential sources: Important implications for clinical researchers
Cortes-Briones JA, Cahill JD, Ranganathan M, Sewell RA, D’Souza D, Skosnik PD. Testing differences in the activity of event-related potential sources: Important implications for clinical researchers. Clinical Neurophysiology 2014, 126: 215-218. PMID: 24840905, DOI: 10.1016/j.clinph.2014.04.008.Peer-Reviewed Original ResearchThe endocannabinoid system and schizophrenia: links to the underlying pathophysiology and to novel treatment approaches.
Gupta S, Cahill JD, Ranganathan M, Correll CU. The endocannabinoid system and schizophrenia: links to the underlying pathophysiology and to novel treatment approaches. The Journal Of Clinical Psychiatry 2014, 75: 285-7. PMID: 24717381, DOI: 10.4088/jcp.14ac08982.Peer-Reviewed Original Research
2010
Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD).
Groom MJ, Cahill JD, Bates AT, Jackson GM, Calton TG, Liddle PF, Hollis C. Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD). Journal Of Child Psychology And Psychiatry, And Allied Disciplines 2010, 51: 66-76. PMID: 19674196, DOI: 10.1111/j.1469-7610.2009.02128.x.Peer-Reviewed Original Research