2011
Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice
Charchaflieh JG, Torres H, Cottrell JE, Kass IS. Posthypoxic Moderate Hypothermia Improves Electrophysiological Recovery in the Rat Hippocampal Slice. Journal Of Neurosurgical Anesthesiology 2011, 23: 146-149. PMID: 21270645, DOI: 10.1097/ana.0b013e31820592d1.Peer-Reviewed Original ResearchConceptsMinutes of hypoxiaRat hippocampal slicesPosthypoxic hypothermiaElectrophysiological recoveryModerate hypothermiaHippocampal slicesCA1 pyramidal cell layerMale Sprague-Dawley ratsHypoxic neuronal injuryPyramidal cell layerSprague-Dawley ratsHours of recoveryNeuronal injuryProtective effectStudy groupInstitutional Animal CareAnimal studiesControl groupHypothermiaElectrophysiological recordingsHypoxiaCell functionUse CommitteeCell layerAnimal care
2009
Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications
Ludvig N, Baptiste SL, Tang HM, Medveczky G, Von Gizycki H, Charchaflieh J, Devinsky O, Kuzniecky RI. Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: Therapeutic implications. Epilepsia 2009, 50: 678-693. PMID: 19055494, DOI: 10.1111/j.1528-1167.2008.01914.x.Peer-Reviewed Original ResearchConceptsMuscimol pretreatmentNeocortical seizuresEEG seizuresAdjacent EEG electrodesFocal neocortical seizuresEffects of AChIntractable focal epilepsySimilar deliveryBehavior of ratsSeizure activityFocal epilepsyAdditional ratsTherapeutic implicationsSubarachnoid spaceMuscimolSeizuresEEG power spectraParietal cortexRatsSquirrel monkeysAChElectroencephalography (EEG) activityMonkeysLast groupACSF
1998
The Effect of Fentanyl on Electrophysiologic Recovery of CA 1 Pyramidal Cells from Anoxia in the Rat Hippocampal Slice
Charchaflieh J, Cottrell J, Kass I. The Effect of Fentanyl on Electrophysiologic Recovery of CA 1 Pyramidal Cells from Anoxia in the Rat Hippocampal Slice. Anesthesia & Analgesia 1998, 87: 68-71.. DOI: 10.1213/00000539-199807000-00015.Peer-Reviewed Original ResearchConceptsEffects of fentanylCA 1 pyramidal cellsMin of anoxiaAnoxic injuryControl groupHippocampal slicesPyramidal cellsRat hippocampal slice modelRat hippocampal slicesAdult Sprague-DawleyHippocampal slice modelSchaffer collateral pathwayRat hippocampal neuronsPreanoxic levelElectrophysiologic recoveryAnoxic insultCollateral pathwaysOpioid receptorsPostsynaptic populationRat hippocampusSuch injuriesSprague-DawleyHippocampal neuronsSurgical proceduresFentanylThe effect of fentanyl on electrophysiologic recovery of CA 1 pyramidal cells from anoxia in the rat hippocampal slice.
Charchaflieh J, Cottrell J, Kass I. The effect of fentanyl on electrophysiologic recovery of CA 1 pyramidal cells from anoxia in the rat hippocampal slice. Anesthesia & Analgesia 1998, 87: 68-71. PMID: 9661548, DOI: 10.1097/00000539-199807000-00015.Peer-Reviewed Original ResearchConceptsEffects of fentanylCA 1 pyramidal cellsMin of anoxiaAnoxic injuryControl groupHippocampal slicesPyramidal cellsRat hippocampal slice modelRat hippocampal slicesAdult Sprague-DawleyHippocampal slice modelSchaffer collateral pathwayRat hippocampal neuronsPreanoxic levelElectrophysiologic recoveryAnoxic insultCollateral pathwaysOpioid receptorsPostsynaptic populationRat hippocampusSuch injuriesSprague-DawleyHippocampal neuronsSurgical proceduresFentanyl