A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation
Miller KS, Khosravi R, Breuer CK, Humphrey JD. A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation. Acta Biomaterialia 2014, 11: 283-294. PMID: 25288519, PMCID: PMC4256111, DOI: 10.1016/j.actbio.2014.09.046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsCompressive StrengthComputer SimulationComputer-Aided DesignElastic ModulusEndothelial CellsEquipment DesignEquipment Failure AnalysisHardnessHumansMaterials TestingModels, ChemicalNeovascularization, PhysiologicPolymersTensile StrengthTissue EngineeringTissue ScaffoldsConceptsScaffold parametersMaterial propertiesScaffold structureParametric studyFibrous scaffoldsScaffold propertiesBurst pressureConstitutive relationsSuture retentionNeotissue developmentTissue engineeringMechanobiological cuesNeovessel developmentFiber diameterNew modeling frameworkExperimental search spaceVascular graftsOptimal combinationPropertiesKey propertiesModeling frameworkParametersNumber of parametersComputational modelNative properties