Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM
Hwang JJ, Jiang L, Hamza M, Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2: e95913. PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.Peer-Reviewed Original ResearchConceptsGlucose levelsPlasma free fatty acid levelsSimilar plasma glucose levelsFree fatty acid levelsCerebral glucose metabolismPlasma glucose levelsBrain glucose levelsFatty acid levelsAltered feeding behaviorGlucose incrementHyperglycemic clampBrain glucoseCerebral functionLean participantsOccipital lobeRodent modelsGlucose metabolismObesityT2DMGlucose responseHyperglycemiaNeurocognitive consequencesSimilar findingsAcid levelsIntracerebral glucose