2024
315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes
SANCHEZ RANGEL E, BELFORT-DEAGUIAR R, LACADIE C, CHUNG T, SCHEINOST D, MASON G, HWANG J. 315-OR: Task-Induced Alterations in the Salience Network amongst Patients with Type 1 Diabetes. Diabetes 2024, 73 DOI: 10.2337/db24-315-or.Peer-Reviewed Original ResearchSalience networkFunctional connectivityCognitive tasksBrain responsesType 1 diabetesBrain functional connectivityResting stateMild hypoglycemiaWorking memoryBrain regionsSalienceContinuous performanceRewardBrainCounterregulatory hormonesStandard preprocessingTaskIndividual traitsMemoryPatientsHypoglycemiaT1DGradCPTStimuliAttention
2018
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia
Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia. Journal Of Clinical Investigation 2018, 128: 1485-1495. PMID: 29381484, PMCID: PMC5873861, DOI: 10.1172/jci97696.Peer-Reviewed Original ResearchConceptsMild hypoglycemiaHypoglycemia awarenessType 1 diabetes mellitus patientsPrefrontal cortexHormonal counterregulatory responsesDiabetes mellitus patientsImpaired hypoglycemia awarenessAltered activation patternsAngular gyrusType 1 diabetesBlood glucose levelsHypoglycemia-induced changesBrain responsesBrain activityHypoglycemia symptom scoresAlters brain activityClinical Translational Science AwardsHyperinsulinemic euglycemicHypoglycemia unawarenessCounterregulatory responsesHypoglycemic clampMellitus patientsMRI brainSymptom scoresNondiabetic individuals