2017
The human brain produces fructose from glucose
Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. The human brain produces fructose from glucose. JCI Insight 2017, 2: e90508. PMID: 28239653, PMCID: PMC5313070, DOI: 10.1172/jci.insight.90508.Peer-Reviewed Original ResearchConceptsPolyol pathwayFructose levelsIntracerebral glucoseBlood-brain barrierPathogenesis of obesityType 2 diabetesEffects of fructoseHuman brainRegression model analysisCNS deliveryCNS effectsHyperglycemic clampHealthy subjectsDietary consumptionGlucoseBaselineBrainMixed-effects regression model analysisFeeding behaviorMinutesCN productionObesityDiabetesLevelsPathogenesis
2015
Fructose Levels Are Markedly Elevated in Cerebrospinal Fluid Compared to Plasma in Pregnant Women
Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. Fructose Levels Are Markedly Elevated in Cerebrospinal Fluid Compared to Plasma in Pregnant Women. PLOS ONE 2015, 10: e0128582. PMID: 26035307, PMCID: PMC4452737, DOI: 10.1371/journal.pone.0128582.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidPregnant womenSorbitol levelsCSF glucoseGlucose levelsCord blood glucoseVenous cord bloodElective cesarean sectionHuman brainBlood-brain barrierPlasma glucose levelsEffects of fructoseCesarean sectionSpinal anesthesiaPlasma levelsBlood glucoseCord bloodObservational studyDietary consumptionPlasma fructoseMaternal plasmaPolyol pathwayBrainDifferential effectsFructose levels