2003
Memory CD4+ T cells do not induce graft-versus-host disease
Anderson BE, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik MJ, Shlomchik WD. Memory CD4+ T cells do not induce graft-versus-host disease. Journal Of Clinical Investigation 2003, 112: 101-108. PMID: 12840064, PMCID: PMC162285, DOI: 10.1172/jci17601.Peer-Reviewed Original ResearchConceptsDonor T cellsMemory CD4 cellsMemory T cellsT cellsHost diseaseCD4 cellsMemory T cell depletionPost-transplant immune reconstitutionAllogeneic stem cell transplantationT cell-mediated immunityT-cell depletionCell-mediated immunityRegulatory T cellsStem cell transplantationStem cell graftsGVHD prophylaxisHistologic GVHDLess GVHDMurine resultsImmune reconstitutionLeukemia effectMemory CD4Naive CD4Cell depletionCell transplantation
2000
Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice
Buchanan K, Doyle H. Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice. Infection And Immunity 2000, 68: 456-462. PMID: 10639404, PMCID: PMC97163, DOI: 10.1128/iai.68.2.456-462.2000.Peer-Reviewed Original ResearchConceptsCentral nervous systemCell-mediated immunityImmune miceT cellsT lymphocytesNervous systemRole of CMIC. neoformansCryptococcus neoformansProtective mechanismT cell numbersSpinal cord homogenateCMI responsesCNS infectionsCryptococcal meningitisLeukocyte accumulationAIDS patientsFatal outcomeImmunized miceVivo depletionCord homogenateIFN-gammaMurine modelHost resistanceCytometric analysis