2018
A univariate perspective of multivariate genome‐wide association analysis
Guo X, Zhu J, Fan Q, He M, Wang X, Zhang H. A univariate perspective of multivariate genome‐wide association analysis. Genetic Epidemiology 2018, 42: 470-479. PMID: 29781551, DOI: 10.1002/gepi.22128.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultivariate genome-wide association studyMultivariate genome-wide association analysisGenome-wide association analysisMultiple correlated phenotypesGenetic signalsAssociation studiesCorrelated phenotypesAssociation analysisMultiple phenotypesSingle phenotypePhenotypeWhole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort
Wen C, Mehta CM, Tan H, Zhang H. Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort. Genetic Epidemiology 2018, 42: 265-275. PMID: 29411414, PMCID: PMC5851842, DOI: 10.1002/gepi.22111.Peer-Reviewed Original ResearchConceptsGenetic markersGenome-wide association study datasetWhole-genome association studiesComplex genetic basisGenome association studiesBrain-wide imaging phenotypesMultivariate phenotypesGenetic basisAssociation studiesGenetic studiesNeuropsychological disordersClinical diagnostic criteriaCovariance testBiological basisPhenotypeDiagnostic criteriaNeuroimaging biomarkersBrain functionBrain structuresPediatric imagingGWASImaging phenotypesDiffusion tensor
2015
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotype
2009
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines
Zhu W, Cho K, Chen X, Zhang M, Wang M, Zhang H. A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines. BMC Proceedings 2009, 3: s119. PMID: 20017984, PMCID: PMC2795891, DOI: 10.1186/1753-6561-3-s7-s119.Peer-Reviewed Original ResearchTraits of interestGenome-wide analysisGenome-wide association studiesWide association analysisGenome-wide dataMultivariate adaptive splinesAssociation studiesAssociation analysisGene-environment interactionsTraitsLongitudinal phenotypesGene-environment interaction effectsMasalFramingham Heart StudyPermutation testGenesPhenotype
2004
Linkage analysis of ordinal traits for pedigree data
Feng R, Leckman JF, Zhang H. Linkage analysis of ordinal traits for pedigree data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16739-16744. PMID: 15548606, PMCID: PMC534720, DOI: 10.1073/pnas.0404623101.Peer-Reviewed Original ResearchConceptsLinkage analysisOrdinal traitsTourette Syndrome Association International ConsortiumLinkage analysis methodsQuantitative traitsEvidence of linkageGenome scanLinkage scanHuman diseasesAllele sharingTraitsPedigree dataInheritance patternDichotomous traitsSignificant allele sharingPhenotypeProportional odds logistic modelGENEHUNTERGenesGeneticsMarkersInternational Consortium