Memory management in genome-wide association studies
Chen X, Zhang M, Wang M, Zhu W, Cho K, Zhang H. Memory management in genome-wide association studies. BMC Proceedings 2009, 3: s54. PMID: 20018047, PMCID: PMC2795954, DOI: 10.1186/1753-6561-3-s7-s54.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesIdentification of genesNorth American Rheumatoid Arthritis Consortium studyGenome-wide associationMemory management toolsMemory management approachCentral processing unitLimited computer memorySignificant computational challengesMemory managementMemory usageProcessing unitMost usersComputational challengesPowerful toolComputer memoryGenesCommon diseaseManagement toolGenotypesWillows: a memory efficient tree and forest construction package
Zhang H, Wang M, Chen X. Willows: a memory efficient tree and forest construction package. BMC Bioinformatics 2009, 10: 130. PMID: 19416535, PMCID: PMC2683818, DOI: 10.1186/1471-2105-10-130.Peer-Reviewed Original ResearchConceptsMassive genotype dataUser-friendly interfaceExcessive memory demandsHigh-dimensional dataNew software packageGenomic dataFriendly interfaceUse of memoryDimensional dataMassive amountsRandom forestPartitioning techniquesHigh-throughput genomic dataPowerful bioinformatics toolsEfficient treeComputer memorySoftware packageMassive sizeForest methodMemory demandsConstruction packagesSingle nucleotide polymorphismsBioinformatics toolsSNP dataGenotyping platforms