2016
Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes & Control 2016, 27: 737-748. PMID: 27125830, PMCID: PMC4870288, DOI: 10.1007/s10552-016-0751-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiabetes MellitusEndometrial NeoplasmsEndometriumEstrogen Receptor alphaEstrogensFemaleGene ExpressionGonadal Steroid HormonesHumansImmunohistochemistryInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMiddle AgedParityPhosphoproteinsPostmenopausePremenopausePTEN PhosphohydrolaseReal-Time Polymerase Chain ReactionReceptor, IGF Type 1Receptor, InsulinReceptors, ProgesteroneReceptors, SomatomedinRisk FactorsRNA, MessengerConceptsInsulin-like growth factorEndometrial cancer risk factorsCancer risk factorsPostmenopausal womenRisk factorsEndometrial tissueInsulin/insulin-like growth factorRegular nonsteroidal anti-inflammatory drug useNonsteroidal anti-inflammatory drug usePhosphorylated insulin-like growth factorEstrogen receptor-positive tissuesAnti-inflammatory drug useNon-diabetic womenProtein levelsReceptor-positive tissuesNormal endometrial tissuesHigher IGFBP1OC usePostmenopausal endometriumBenign indicationsProgesterone receptorQuantitative real-time PCRHormone axesIGFBP3 expressionHuman endometrium
2015
PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors
Yang HP, Meeker A, Guido R, Gunter MJ, Huang GS, Luhn P, d’Ambrosio L, Wentzensen N, Sherman ME. PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors. Cancer Causes & Control 2015, 26: 1729-1736. PMID: 26376893, PMCID: PMC4628559, DOI: 10.1007/s10552-015-0666-5.Peer-Reviewed Original ResearchConceptsEndometrial cancer risk factorsCancer risk factorsEndometrial cancer tissuesEndometrial tissueRisk factorsBenign endometriumNSAID usePTEN lossEndometrial cancerEndometrial glandsPTEN expressionExact testCancer tissuesPopulation-based case-control studyBenign endometrial samplesBenign endometrial tissuesMost risk factorsHuman endometrial tissueCase-control studyFisher's exact testEndometrial hyperplasiaEndometrial carcinomaEndometrial samplesEutopic endometriumImmunohistochemical study