2018
Female Sex Hormone Receptor Profiling in Uterine Adenosarcomas
Marcus JZ, Klobocista M, Karabakhtsian RG, Prossnitz E, Goldberg GL, Huang GS. Female Sex Hormone Receptor Profiling in Uterine Adenosarcomas. International Journal Of Gynecological Cancer 2018, 28: 500-504. PMID: 29303935, PMCID: PMC6125779, DOI: 10.1097/igc.0000000000001183.Peer-Reviewed Original ResearchMeSH KeywordsAdenosarcomaEstrogen Receptor alphaEstrogen Receptor betaFemaleHumansMiddle AgedReceptors, EstrogenReceptors, G-Protein-CoupledReceptors, ProgesteroneUterine NeoplasmsConceptsG protein-coupled estrogen receptorHigh-grade featuresHigh-grade tumorsCases of ASReceptor statusGPER expressionTumor samplesUterine adenosarcomaH-scoreHigh-grade histologic featuresProtein-coupled estrogen receptorHormonal receptor statusProgesterone receptor statusEstrogen receptor statusEstrogen receptor βEstrogen receptor αIntensity of stainingTumor tissue sectionsClinicopathologic dataHistologic featuresSarcomatous overgrowthUterine carcinosarcomaHistologic diagnosisMedical recordsEstrogen receptor
2016
Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes & Control 2016, 27: 737-748. PMID: 27125830, PMCID: PMC4870288, DOI: 10.1007/s10552-016-0751-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiabetes MellitusEndometrial NeoplasmsEndometriumEstrogen Receptor alphaEstrogensFemaleGene ExpressionGonadal Steroid HormonesHumansImmunohistochemistryInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMiddle AgedParityPhosphoproteinsPostmenopausePremenopausePTEN PhosphohydrolaseReal-Time Polymerase Chain ReactionReceptor, IGF Type 1Receptor, InsulinReceptors, ProgesteroneReceptors, SomatomedinRisk FactorsRNA, MessengerConceptsInsulin-like growth factorEndometrial cancer risk factorsCancer risk factorsPostmenopausal womenRisk factorsEndometrial tissueInsulin/insulin-like growth factorRegular nonsteroidal anti-inflammatory drug useNonsteroidal anti-inflammatory drug usePhosphorylated insulin-like growth factorEstrogen receptor-positive tissuesAnti-inflammatory drug useNon-diabetic womenProtein levelsReceptor-positive tissuesNormal endometrial tissuesHigher IGFBP1OC usePostmenopausal endometriumBenign indicationsProgesterone receptorQuantitative real-time PCRHormone axesIGFBP3 expressionHuman endometrium
2010
Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma
Huang GS, Gunter MJ, Arend RC, Li M, Arias-Pulido H, Prossnitz ER, Goldberg GL, Smith HO. Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. American Journal Of Obstetrics And Gynecology 2010, 203: 242.e1-242.e5. PMID: 20605134, PMCID: PMC2933955, DOI: 10.1016/j.ajog.2010.04.046.Peer-Reviewed Original ResearchConceptsUterine carcinosarcomaProgesterone receptorDisease progressionEpithelial expressionG protein-coupled receptor 30Early-stage carcinosarcomaAdvanced stage diseaseExpression of GPR30Expression levelsWilcoxon rank sum testRank sum testLower ERalphaReceptor 30PR expressionNormal endometriumEstrogen receptorGPR30Positive cellsCarcinosarcomaLogistic regressionERbetaSum testERalphaAlternative ERsTissue sections
2009
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma
Huang GS, Arend RC, Li M, Gunter MJ, Chiu LG, Horwitz SB, Goldberg GL. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. American Journal Of Obstetrics And Gynecology 2009, 200: 457.e1-457.e5. PMID: 19200930, PMCID: PMC2676778, DOI: 10.1016/j.ajog.2008.12.012.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2 (HER2) expressionEpidermal growth factor receptor 2 expressionEstrogen receptor beta expressionGrowth factor receptor expressionEstrogen receptor betaReceptor 2 expressionDisease progressionReceptor expressionEstrogen receptor alphaFactor receptor expressionNormal endometriumUterine carcinosarcomaBeta expressionReceptor alphaReceptor betaHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Insulin-like growth factor receptor expressionAdvanced stage diseaseGrowth factor receptor 2Progesterone receptor expressionInsulin-like growth factor receptorTissue microarray analysisFactor receptor 2Wilcoxon rank sum test