2018
Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors
Li C, Bonazzoli E, Bellone S, Choi J, Dong W, Menderes G, Altwerger G, Han C, Manzano A, Bianchi A, Pettinella F, Manara P, Lopez S, Yadav G, Riccio F, Zammataro L, Zeybek B, Yang-Hartwich Y, Buza N, Hui P, Wong S, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Zizioli V, Odicino F, Pecorelli S, Ardighieri L, Silasi DA, Litkouhi B, Ratner E, Azodi M, Huang GS, Schwartz PE, Lifton RP, Schlessinger J, Santin AD. Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 116: 619-624. PMID: 30584090, PMCID: PMC6329978, DOI: 10.1073/pnas.1814027116.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsAzepinesBRCA1 ProteinBRCA2 ProteinCell Line, TumorClass I Phosphatidylinositol 3-KinasesFemaleHumansMiceMutationNeoplasm MetastasisNeoplasm Recurrence, LocalOvarian NeoplasmsProteinsProto-Oncogene Proteins c-mycTriazolesTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsOvarian cancerWhole-exome sequencingC-myc amplificationRecurrent tumorsPrimary tumorBET inhibitorsChemotherapy-resistant diseaseRecurrent ovarian cancerLethal gynecologic malignancyBilateral ovarian cancerChemotherapy-resistant tumorsPrimary metastatic tumorsMutational landscapeSomatic mutationsFresh-frozen tumorsGynecologic malignanciesMetastatic tumorsPrimary cell linesC-MYC gainPIK3CA amplificationTranscoelomic metastasisTherapeutic targetPatientsMetastatic abilityTumors
2015
Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor
Schwartz M, Huang GS. Retreatment with aromatase inhibitor therapy in the management of granulosa cell tumor. Gynecologic Oncology Reports 2015, 15: 20-21. PMID: 26937482, PMCID: PMC4750011, DOI: 10.1016/j.gore.2015.12.004.Peer-Reviewed Case Reports and Technical Notes
2011
Clinical utility of chromogranin A and octerotide in large cell neuro endocrine carcinoma of the uterine corpus
Shahabi S, Pellicciotta I, Hou J, Graceffa S, Huang GS, Samuelson RN, Goldberg GL. Clinical utility of chromogranin A and octerotide in large cell neuro endocrine carcinoma of the uterine corpus. Rare Tumors 2011, 3: 41. PMID: 22355496, PMCID: PMC3282446, DOI: 10.4081/rt.2011.e41.Peer-Reviewed Original ResearchLarge cell neuroendocrine carcinomaNeuroendocrine tumorsUterine corpusGenital tractLarge cell neuro endocrine carcinomaLarge cell neuroendocrine tumorNeuro-endocrine carcinomaPrimary neuroendocrine tumorCell neuroendocrine carcinomaFemale genital tractPotential future therapeuticsEndocrine carcinomaAggressive treatmentInitial diagnosisUterine cervixNeuroendocrine carcinomaTreatment optionsRare caseClinical utilityChromogranin AOptimal managementTumorsFuture therapeuticsCervixCarcinoma
2007
Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors
Huang GS, Gebb JS, Einstein MH, Shahabi S, Novetsky AP, Goldberg GL. Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. American Journal Of Obstetrics And Gynecology 2007, 196: 243.e1-243.e5. PMID: 17346538, DOI: 10.1016/j.ajog.2006.09.035.Peer-Reviewed Original ResearchConceptsHigh-grade endometrial tumorsPreoperative endometrial samplingEndometrial samplingEndometrial tumorsEndometrial cancer patientsHigh-grade cancerLow-grade cancerNonendometrioid histologyPathologic reviewHysterectomy specimensSingle institutionCancer patientsHistologic diagnosisTumor gradePipelleCurettageTumorsPatientsDiagnosisKappa statisticsCancerHistology