RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma
Mi S, Lin M, Brouwer-Visser J, Heim J, Smotkin D, Hebert T, Gunter MJ, Goldberg GL, Zheng D, Huang GS. RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma. Clinical Cancer Research 2016, 22: 4676-4686. PMID: 27121792, DOI: 10.1158/1078-0432.ccr-15-2116.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinosarcomaCase-Control StudiesCell MovementFemaleGene ExpressionGene Expression ProfilingGTPase-Activating ProteinsHigh-Throughput Nucleotide SequencingHumansInhibitor of Apoptosis ProteinsMiddle AgedNeoplasm MetastasisNeoplasm StagingSTAT3 Transcription FactorSurvivinTranscriptomeUterine NeoplasmsConceptsUterine carcinosarcomaTherapeutic targetCell line-derived xenograft modelSurvivin expressionRare aggressive malignancyPrimary surgical resectionHigh relapse rateNormal endometrial tissuesNovel therapeutic targetCarcinosarcoma cell lineEndometrial adenocarcinoma cellsFunctional assaysCell linesExtrauterine spreadPostmenopausal womenCancer Genome AtlasMedian survivalSurgical resectionExtrauterine metastasesRelapse rateBenign indicationsEndometrial tissueAggressive malignancyPoor responseTCGA cohort