Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer
Burton ER, Gaffar A, Lee SJ, Adeshuko F, Whitney KD, Chung JY, Hewitt SM, Huang GS, Goldberg GL, Libutti SK, Kwon M. Downregulation of Filamin A Interacting Protein 1-Like is Associated with Promoter Methylation and Induces an Invasive Phenotype in Ovarian Cancer. Molecular Cancer Research 2011, 9: 1126-1138. PMID: 21693594, PMCID: PMC3157597, DOI: 10.1158/1541-7786.mcr-11-0162.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsCell LineCell Line, TumorCell MovementCell ProliferationCpG IslandsCyclic AMP Response Element-Binding ProteinCytoskeletal ProteinsDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessNeoplasm StagingOvarian NeoplasmsPhenotypePromoter Regions, GeneticConceptsOvarian cancer cellsFILIP1L expressionOvarian cancerCAMP-responsive element binding proteinCancer cellsClinical ovarian cancer specimensFive-year survival rateMore effective therapeutic interventionsInvasive phenotypeLethal gynecologic malignancyOvarian cancer cell linesNormal ovarian epithelial cellsOvarian cancer specimensOvarian cancer invasionOvarian cancer therapyEffective therapeutic interventionsCell linesOvarian epithelial cellsOvarian cell linesCancer cell linesGynecologic malignanciesOvarian specimensCancer specimensStage IIIDNA demethylating agent