2016
RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma
Mi S, Lin M, Brouwer-Visser J, Heim J, Smotkin D, Hebert T, Gunter MJ, Goldberg GL, Zheng D, Huang GS. RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma. Clinical Cancer Research 2016, 22: 4676-4686. PMID: 27121792, DOI: 10.1158/1078-0432.ccr-15-2116.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinosarcomaCase-Control StudiesCell MovementFemaleGene ExpressionGene Expression ProfilingGTPase-Activating ProteinsHigh-Throughput Nucleotide SequencingHumansInhibitor of Apoptosis ProteinsMiddle AgedNeoplasm MetastasisNeoplasm StagingSTAT3 Transcription FactorSurvivinTranscriptomeUterine NeoplasmsConceptsUterine carcinosarcomaTherapeutic targetCell line-derived xenograft modelSurvivin expressionRare aggressive malignancyPrimary surgical resectionHigh relapse rateNormal endometrial tissuesNovel therapeutic targetCarcinosarcoma cell lineEndometrial adenocarcinoma cellsFunctional assaysCell linesExtrauterine spreadPostmenopausal womenCancer Genome AtlasMedian survivalSurgical resectionExtrauterine metastasesRelapse rateBenign indicationsEndometrial tissueAggressive malignancyPoor responseTCGA cohortInsulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors
Merritt MA, Strickler HD, Einstein MH, Yang HP, Sherman ME, Wentzensen N, Brouwer-Visser J, Cossio MJ, Whitney KD, Yu H, Gunter MJ, Huang GS. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors. Cancer Causes & Control 2016, 27: 737-748. PMID: 27125830, PMCID: PMC4870288, DOI: 10.1007/s10552-016-0751-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiabetes MellitusEndometrial NeoplasmsEndometriumEstrogen Receptor alphaEstrogensFemaleGene ExpressionGonadal Steroid HormonesHumansImmunohistochemistryInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMiddle AgedParityPhosphoproteinsPostmenopausePremenopausePTEN PhosphohydrolaseReal-Time Polymerase Chain ReactionReceptor, IGF Type 1Receptor, InsulinReceptors, ProgesteroneReceptors, SomatomedinRisk FactorsRNA, MessengerConceptsInsulin-like growth factorEndometrial cancer risk factorsCancer risk factorsPostmenopausal womenRisk factorsEndometrial tissueInsulin/insulin-like growth factorRegular nonsteroidal anti-inflammatory drug useNonsteroidal anti-inflammatory drug usePhosphorylated insulin-like growth factorEstrogen receptor-positive tissuesAnti-inflammatory drug useNon-diabetic womenProtein levelsReceptor-positive tissuesNormal endometrial tissuesHigher IGFBP1OC usePostmenopausal endometriumBenign indicationsProgesterone receptorQuantitative real-time PCRHormone axesIGFBP3 expressionHuman endometrium
2015
Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse
Leegant A, Zuckerwise LC, Downing K, Brouwer-Visser J, Zhu C, Cossio MJ, Strube F, Xie X, Banks E, Huang GS. Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse. Urogynecology 2015, 21: 53-58. PMID: 25185601, PMCID: PMC4344824, DOI: 10.1097/spv.0000000000000130.Peer-Reviewed Original ResearchConceptsPelvic organ prolapseTGF-β1 expressionMMP-9 expressionTGF-β1Uterosacral ligamentsMMP-9Vaginal hysterectomyOrgan prolapseSmooth muscleFibrous tissueGreater pelvic organ prolapseGrowth factor-β1 expressionInstitutional review board approvalMatrix metalloproteinase-9Review board approvalAge-related alterationsGrowth factor-β1Benign indicationsMetalloproteinase-9Clinical dataImmunohistochemical stainingBoard approvalTrichrome stainingFactor-β1Β1 expression