2017
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromiseAspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway
Mottola G, Chatterjee A, Wu B, Chen M, Conte MS. Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. PLOS ONE 2017, 12: e0174936. PMID: 28362840, PMCID: PMC5376330, DOI: 10.1371/journal.pone.0174936.Peer-Reviewed Original ResearchConceptsAT-RvD1Vascular smooth muscle cell migrationALX/FPR2Smooth muscle cell migrationVSMC migrationMuscle cell migrationRp-8-BrResolvin D1Specialized pro-resolving lipid mediatorsAspirin-triggered resolvin D1Pro-resolving lipid mediatorsCyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathwayCAMP levelsHuman saphenous veinPlatelet-derived growth factorTreatment of VSMCCell migrationPKA activityIntracellular cAMP levelsCAMP/PKA pathwaySaphenous veinRac1 activityRvD1 receptorIntimal hyperplasiaLipid mediators
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchConceptsResolvin D1Rat carotid artery modelProresolving lipid mediatorsHuman vascular endothelialNF-κB activationSmooth muscle cellsCarotid artery modelTissue injuryEvidence of cytotoxicityRvD1Lipid mediatorsRabbit aortaVSMC migrationMuscle cellsFlow chamber systemBlood vesselsLocal deliveryVascular endothelialArtery modelRelevant levelsVivoTissueD1Vascular tissueDays