Giorgio Mottola, MD
Clinical FellowAbout
Research
Publications
2022
17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury
Kim AS, Werlin EC, Kagaya H, Chen M, Wu B, Mottola G, Jan M, Conte MS. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury. PLOS ONE 2022, 17: e0264217. PMID: 35226675, PMCID: PMC8884511, DOI: 10.1371/journal.pone.0264217.Peer-Reviewed Original ResearchOut to the tissues: the arterial side (arteries, arterioles—development, structure, functions, and pathologies)
Dave J, Saito J, Mottola G, Grief DM. Chapter 8, Out to the tissues: the arterial side (arteries, arterioles—development, structure, functions, and pathologies). In: Galis ZS (Ed). The Vasculome: From Many, One. San Diego: Elsevier Inc./Academic Press, 2022: 89-96Chapters
2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original Research
2018
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime Factors
2017
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBiosynthesis of proresolving lipid mediators by vascular cells and tissues
Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. The FASEB Journal 2017, 31: 3393-3402. PMID: 28442547, PMCID: PMC6207217, DOI: 10.1096/fj.201700082r.Peer-Reviewed Original ResearchAspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway
Mottola G, Chatterjee A, Wu B, Chen M, Conte MS. Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. PLOS ONE 2017, 12: e0174936. PMID: 28362840, PMCID: PMC5376330, DOI: 10.1371/journal.pone.0174936.Peer-Reviewed Original Research
2016
Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device
Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. Journal Of Biomedical Materials Research Part A 2016, 105: 31-41. PMID: 27508346, PMCID: PMC5124518, DOI: 10.1002/jbm.a.35861.Peer-Reviewed Original ResearchPerivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury
Wu B, Mottola G, Chatterjee A, Lance KD, Chen M, Siguenza IO, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury. Journal Of Vascular Surgery 2016, 65: 207-217.e3. PMID: 27034112, PMCID: PMC5040608, DOI: 10.1016/j.jvs.2016.01.030.Peer-Reviewed Original ResearchAngioplasty, BalloonAnimalsAortaCardiovascular AgentsCarotid Artery DiseasesCell MovementCell ProliferationCells, CulturedCytoskeletonDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersDrug CompoundingHyperplasiaInflammation MediatorsKi-67 AntigenLactic AcidMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaOxidative StressPoloxamerPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRats, Sprague-DawleyTime FactorsTranscription Factor RelA
2014
The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells
Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS. The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells. PLOS ONE 2014, 9: e113480. PMID: 25409514, PMCID: PMC4237455, DOI: 10.1371/journal.pone.0113480.Peer-Reviewed Original ResearchCell AdhesionCells, CulturedCyclic AMPDocosahexaenoic AcidsDown-RegulationE-SelectinEndothelial CellsHumansMuscle, Smooth, VascularNADPH OxidasesNF-kappa BOxidative StressPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaU937 CellsUp-Regulation