2024
TRPS1 expression in MPNST is correlated with PRC2 inactivation and loss of H3K27me3
Lazcano R, Ingram D, Panse G, Lazar A, Wang W, Cloutier J. TRPS1 expression in MPNST is correlated with PRC2 inactivation and loss of H3K27me3. Human Pathology 2024, 151: 105632. PMID: 39084565, DOI: 10.1016/j.humpath.2024.105632.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumorTrichorhinophalangeal syndrome type 1TRPS1 expressionPeripheral nerve sheath tumorsNerve sheath tumorsLoss of H3K27me3Sheath tumorsNon-mammary tumorsPRC2 inactivationCellular neurofibromaAtypical neurofibromaImmunohistochemical expressionImmunohistochemical markersMammary originNeurofibromasTumorIntense stainingType 1Schwannoma
2017
The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours
Panse G, Leung CH, Ingram DR, Wani K, Torres KE, Lin H, Lazar AJ, Wang W. The role of phosphorylated signal transducer and activator of transcription 3 (pSTAT3) in peripheral nerve sheath tumours. Histopathology 2017, 70: 946-953. PMID: 27992966, DOI: 10.1111/his.13154.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-specific overall survivalEvent-free survivalPrimary malignant peripheral nerve sheath tumorPeripheral nerve sheath tumorsWorse event-free survivalKaplan-Meier methodNegative prognostic factorNerve sheath tumorsLog-rank testPeripheral nerve sheathParaffin-embedded tissue microarrayPhosphorylated STAT3 expressionPhosphorylated signal transducerMetastatic diseaseOverall survivalPrognostic factorsSheath tumorsAggressive diseaseNerve sheathPro-oncogenic transcription factorPrimary tumorDisease onsetTissue microarrayImmunohistochemical analysis