2021
Brain connectivity inversely scales with developmental temperature in Drosophila
Kiral F, Dutta S, Linneweber G, Hilgert S, Poppa C, Duch C, von Kleist M, Hassan B, Hiesinger P. Brain connectivity inversely scales with developmental temperature in Drosophila. Cell Reports 2021, 37: 110145. PMID: 34936868, DOI: 10.1016/j.celrep.2021.110145.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAxonsBrainDrosophilaDrosophila ProteinsNeurogenesisNeuronsPhotoreceptor Cells, InvertebrateSynapsesTemperatureSystematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
Kohrs F, Daumann I, Pavlovic B, Jin E, Kiral F, Lin S, Port F, Wolfenberg H, Mathejczyk T, Linneweber G, Chan C, Boutros M, Hiesinger P. Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies. ELife 2021, 10: e59594. PMID: 33666175, PMCID: PMC8016483, DOI: 10.7554/elife.59594.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophila melanogasterDrosophila ProteinsGene Knock-In TechniquesImidazolesNeuronsRab GTP-Binding ProteinsTemperatureConceptsRab GTPasesMembrane traffickingSystematic functional analysisObvious morphological defectsAutophagy-independent roleMutant collectionNull mutantsFertile fliesMaintenance defectsGTPasesNeuronal robustnessFunctional analysisMolecular switchMorphological defectsUnknown functionHalf exhibitMutantsFliesNeuronal functionGenesTraffickingEnvironmental challengesRabRab26Nervous system
2020
Generation and characterization of inner photoreceptor‐specific enhancer‐trap lines using a novel piggyBac‐Gal4 element in Drosophila
Kara E, Kiral F, Çolak A, Çelik A. Generation and characterization of inner photoreceptor‐specific enhancer‐trap lines using a novel piggyBac‐Gal4 element in Drosophila. Archives Of Insect Biochemistry And Physiology 2020, 104: e21675. PMID: 32285519, DOI: 10.1002/arch.21675.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationDNA Transposable ElementsDrosophilaDrosophila ProteinsLarvaPhotoreceptor Cells, InvertebratePupaTranscription FactorsAutophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring
Kiral F, Linneweber G, Mathejczyk T, Georgiev S, Wernet M, Hassan B, von Kleist M, Hiesinger P. Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring. Nature Communications 2020, 11: 1325. PMID: 32165611, PMCID: PMC7067798, DOI: 10.1038/s41467-020-14781-4.Peer-Reviewed Original Research
2019
Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors
Özel M, Kulkarni A, Hasan A, Brummer J, Moldenhauer M, Daumann I, Wolfenberg H, Dercksen V, Kiral F, Weiser M, Prohaska S, von Kleist M, Hiesinger P. Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors. Developmental Cell 2019, 50: 447-461.e8. PMID: 31353313, PMCID: PMC6702111, DOI: 10.1016/j.devcel.2019.06.014.Peer-Reviewed Original Research
2018
Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals
Jin E, Kiral F, Ozel M, Burchardt L, Osterland M, Epstein D, Wolfenberg H, Prohaska S, Hiesinger P. Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals. Current Biology 2018, 28: 1027-1038.e4. PMID: 29551411, PMCID: PMC5944365, DOI: 10.1016/j.cub.2018.02.032.Peer-Reviewed Original ResearchConceptsSynaptic vesicle proteinsMembrane proteinsVesicle proteinsLive-imaging approachesPlasma membrane proteinsMembrane protein degradationIntact Drosophila brainsProtein degradation mechanismsMembrane cargoDegradative compartmentsNeuronal synaptobrevinProtein degradationDrosophila brainContinuous turnoverCell bodiesProteinDegradation pathwayLive observationDistinct classesSortingCargoCompartmentsSynaptobrevinDegradationRab7