2021
Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies
Kohrs F, Daumann I, Pavlovic B, Jin E, Kiral F, Lin S, Port F, Wolfenberg H, Mathejczyk T, Linneweber G, Chan C, Boutros M, Hiesinger P. Systematic functional analysis of Rab GTPases reveals limits of neuronal robustness to environmental challenges in flies. ELife 2021, 10: e59594. PMID: 33666175, PMCID: PMC8016483, DOI: 10.7554/elife.59594.Peer-Reviewed Original ResearchConceptsRab GTPasesMembrane traffickingSystematic functional analysisObvious morphological defectsAutophagy-independent roleMutant collectionNull mutantsFertile fliesMaintenance defectsGTPasesNeuronal robustnessFunctional analysisMolecular switchMorphological defectsUnknown functionHalf exhibitMutantsFliesNeuronal functionGenesTraffickingEnvironmental challengesRabRab26Nervous system
2018
Rab GTPases and Membrane Trafficking in Neurodegeneration
Kiral F, Kohrs F, Jin E, Hiesinger P. Rab GTPases and Membrane Trafficking in Neurodegeneration. Current Biology 2018, 28: r471-r486. PMID: 29689231, PMCID: PMC5965285, DOI: 10.1016/j.cub.2018.02.010.Peer-Reviewed Original ResearchConceptsMembrane traffickingRab GTPasesCellular responsesRab GTPase functionGTPase functionMembrane compartmentsGTPasesKey regulatorSecondary consequenceHallmark of neurodegenerationTraffickingSecondary correlateDrivers of pathologyCurrent knowledgeNeurodegenerationHuntington's diseaseMembraneDifferent rolesRegulatorAlzheimer's diseaseCompartmentsDefectsHallmarkDirect consequenceFunction