2024
Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory
Cellini B, Baum M, Frishberg Y, Groothoff J, Harris P, Hulton S, Knauf F, Knight J, Lieske J, Lowther W, Moochhala S, Nazzal L, Tasian G, Whittamore J, Sas D. Opportunities in Primary and Enteric Hyperoxaluria at the Cross-Roads Between the Clinic and Laboratory. Kidney International Reports 2024, 9: 3083-3096. PMID: 39534212, PMCID: PMC11551133, DOI: 10.1016/j.ekir.2024.08.031.Peer-Reviewed Original Research
2020
Pathophysiology and Treatment of Enteric Hyperoxaluria
Witting C, Langman C, Assimos D, Baum M, Kausz A, Milliner D, Tasian G, Worcester E, Allain M, West M, Knauf F, Lieske J. Pathophysiology and Treatment of Enteric Hyperoxaluria. Clinical Journal Of The American Society Of Nephrology 2020, 16: 487-495. PMID: 32900691, PMCID: PMC8011014, DOI: 10.2215/cjn.08000520.Peer-Reviewed Original ResearchConceptsEnteric hyperoxaluriaGastrointestinal disordersBariatric surgical proceduresCurrent therapeutic optionsAvailable treatment strategiesUrinary oxalate excretionKidney stone eventsLong-term efficacyKidney Health InitiativeNew therapeutic approachesComplicated obesityDietary modificationFat malabsorptionOxalate excretionTherapeutic optionsAdverse outcomesKidney failureStone eventsTreatment strategiesDietary oxalateSurgical proceduresTherapeutic approachesSevere casesHyperoxaluriaHealth initiatives
2013
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.Peer-Reviewed Original ResearchConceptsProgressive renal failureRenal failureCalcium oxalate crystal depositionCrystal-associated diseasesOverproduction of oxalateWild-type miceHigh-oxalate dietNephropathy resultsOxalate nephropathyRenal histologyKidney diseaseOxalate dietInflammatory responseNALP3 expressionDietary oxalateIntestinal oxalateOxalate homeostasisSoluble oxalateNephropathyCrystal depositionMiceMultiple disordersNALP3DietInflammation