2014
Lyme Disease
Solomon C, Shapiro E. Lyme Disease. New England Journal Of Medicine 2014, 370: 1724-1731. PMID: 24785207, PMCID: PMC4487875, DOI: 10.1056/nejmcp1314325.Peer-Reviewed Original Research
2007
A Critical Appraisal of “Chronic Lyme Disease”
Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBorrelia burgdorferi GroupChronic DiseaseControlled Clinical Trials as TopicDiagnosis, DifferentialHumansLyme DiseasePatient SelectionConceptsAcute Lyme diseaseChronic Lyme diseaseLyme diseasePersistent painNeurocognitive symptomsCommon tick-borne infectionSerious public health problemPublic health problemTick-borne infectionsBorrelia burgdorferi sensu strictoBurgdorferi sensu strictoHealth problemsDiseasePainPatientsSymptomsFatigueInfectionDiagnosis
2004
Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias
Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias. The Pediatric Infectious Disease Journal 2004, 23: 127-131. PMID: 14872178, DOI: 10.1097/01.inf.0000109248.32907.1d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBacterial CapsulesBiasCase-Control StudiesChild, PreschoolConfidence IntervalsFemaleHaemophilus InfectionsHaemophilus influenzae type bHaemophilus VaccinesHumansImmunityImmunization ScheduleInfantMalePolysaccharides, BacterialProbabilityReference ValuesReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeVaccinationConceptsEffectiveness of vaccinesCase-control studyInvasive Hib infectionsHib vaccinePneumococcal infectionHib infectionsInvasive infectionsHaemophilus influenzae type bInvasive pneumococcal infectionsInfluenzae type bMonths of ageIdentical study designOverall 34Study 74S. pneumoniaeStreptococcus pneumoniaeVaccineInfectionStudy designHibType BPneumoniaeValid methodCasesPotential bias
2000
Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus
King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAntibody levelsSerum samplesPneumococcal illnessImmunodeficiency virusPneumococcal antibody levelsGeometric mean levelsAntibody valuesPneumococcal serotypesIgG antibodiesGroup 4Mean levelsSeroresponsesIllnessChildrenWeeksSerotypesVirusLevelsSerorespondersELISAAntibodies
1996
Lyme Disease in Children in Southeastern Connecticut
Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.Peer-Reviewed Original ResearchConceptsErythema migrans lesionsSingle erythema migrans lesionLyme diseaseErythema migransClinical manifestationsMultiple erythema migrans lesionsCommunity-based cohort studyFacial nerve palsyInitial clinical manifestationPrompt clinical responseEarly Lyme diseasePercent of childrenConventional antimicrobial therapyMultiple erythemaClinical responseCohort studyAseptic meningitisConsecutive patientsMedian ageProspective dataAntimicrobial therapyAntibody testNew episodesPatientsLesions
1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmoxicillinAnimalsAntibodies, BacterialBites and StingsChildDouble-Blind MethodFemaleFollow-Up StudiesHumansLyme DiseaseMaleRiskTicksConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferi