2014
Lyme Disease
Solomon C, Shapiro E. Lyme Disease. New England Journal Of Medicine 2014, 370: 1724-1731. PMID: 24785207, PMCID: PMC4487875, DOI: 10.1056/nejmcp1314325.Peer-Reviewed Original Research
2009
A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH
Marques A, Shaw P, Schmid C, Steere A, Kaplan R, Hassett A, Shapiro E, Wormser G. A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF REPEATED IV ANTIBIOTIC THERAPY FOR LYME ENCEPHALOPATHY PROLONGED LYME DISEASE TREATMENT: ENOUGH IS ENOUGH. Neurology 2009, 72: 383-386. PMID: 19171842, DOI: 10.1212/01.wnl.0000343855.45704.7c.Peer-Reviewed Original Research
2007
A Critical Appraisal of “Chronic Lyme Disease”
Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.Peer-Reviewed Original ResearchConceptsAcute Lyme diseaseChronic Lyme diseaseLyme diseasePersistent painNeurocognitive symptomsCommon tick-borne infectionSerious public health problemPublic health problemTick-borne infectionsBorrelia burgdorferi sensu strictoBurgdorferi sensu strictoHealth problemsDiseasePainPatientsSymptomsFatigueInfectionDiagnosis
2006
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchMeSH KeywordsAnaplasmosisAnimalsBabesiosisEhrlichiosisHealth PersonnelHumansLyme DiseaseSyndromeTick-Borne DiseasesConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfection
2000
Lyme Disease
Shapiro E, Gerber M. Lyme Disease. Clinical Infectious Diseases 2000, 31: 533-542. PMID: 10987718, DOI: 10.1086/313982.Peer-Reviewed Original ResearchConceptsLyme diseaseCommon vector borne diseaseSeventh cranial nerve palsyOnly nonspecific symptomsCranial nerve palsyAnnular rashNerve palsyNonspecific symptomsAseptic meningitisSymptomatic infectionFrequent manifestationCommon causeActual morbidityPossible diagnosisSerological testsMost personsDiseaseBorrelia burgdorferiSymptomsVector borne diseasesBorne diseasesFrequent useManifestationsUnited StatesCausePractice Guidelines for the Treatment of Lyme Disease
Wormser G, Nadelman R, Dattwyler R, Dennis D, Shapiro E, Steere A, Rush T, Rahn D, Coyle P, Persing D, Fish D, Luft B. Practice Guidelines for the Treatment of Lyme Disease. Clinical Infectious Diseases 2000, 31: s1-s14. PMID: 10982743, DOI: 10.1086/314053.Peer-Reviewed Original Research
1998
Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes
Gerber M, Zemel L, Shapiro E. Lyme Arthritis in Children: Clinical Epidemiology and Long-term Outcomes. Pediatrics 1998, 102: 905-908. PMID: 9755263, DOI: 10.1542/peds.102.4.905.Peer-Reviewed Original ResearchConceptsLong-term outcomesLyme arthritisAppropriate antimicrobial therapyAntimicrobial therapyClinical epidemiologyLyme diseaseMean white blood cell countWhite blood cell countNewington Children's HospitalCells/mm3Pediatric rheumatology clinicTime of diagnosisEarly Lyme diseaseErythrocyte sedimentation rateLong-term followOnset of symptomsBlood cell countStructured telephone interviewActive arthritisChronic arthritisRheumatology clinicArthroscopic synovectomyInitial diagnosisChildren's HospitalTelephone followLyme Disease
Shapiro E. Lyme Disease. Pediatrics In Review 1998, 19: 147-154. PMID: 9584524, DOI: 10.1542/pir.19-5-147.Peer-Reviewed Original Research
1997
Lyme Disease in Children
Shapiro E, Seltzer E. Lyme Disease in Children. Seminars In Neurology 1997, 17: 39-44. PMID: 9166958, DOI: 10.1055/s-2008-1040911.ChaptersMeSH KeywordsAdultChildChild, PreschoolHumansInfantInfant, NewbornLyme DiseaseNervous System Diseases
1996
Lyme Disease in Children in Southeastern Connecticut
Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.Peer-Reviewed Original ResearchConceptsErythema migrans lesionsSingle erythema migrans lesionLyme diseaseErythema migransClinical manifestationsMultiple erythema migrans lesionsCommunity-based cohort studyFacial nerve palsyInitial clinical manifestationPrompt clinical responseEarly Lyme diseasePercent of childrenConventional antimicrobial therapyMultiple erythemaClinical responseCohort studyAseptic meningitisConsecutive patientsMedian ageProspective dataAntimicrobial therapyAntibody testNew episodesPatientsLesionsMisdiagnosis of Lyme disease: when not to order serologic tests.
Seltzer EG, Shapiro ED. Misdiagnosis of Lyme disease: when not to order serologic tests. The Pediatric Infectious Disease Journal 1996, 15: 762-3. PMID: 8878216, DOI: 10.1097/00006454-199609000-00003.Peer-Reviewed Original Research
1994
Lyme Disease
Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. PMID: 8036192, DOI: 10.1542/pir.15-5-167.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLyme diseaseLyme borreliosisCommon vector-borne diseaseIxodes ticksNymphal Ixodes ticksUnexplained arthritisLyme arthritisClinical manifestationsBacterial etiologyClusters of childrenBorrelia burgdoferiMedical attentionSystemic infectionArthritisDistinct entityDiseaseBorrelia burgdorferiPencil pointVector-borne diseasesBorreliosisTicksWood tickPatientsEtiologyYears
1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferiDiagnosis of Lyme disease in children
Gerber M, Shapiro E. Diagnosis of Lyme disease in children. The Journal Of Pediatrics 1992, 121: 157-162. PMID: 1625075, DOI: 10.1016/s0022-3476(05)82569-7.Peer-Reviewed Original Research