2024
Tick-borne infections in children in North America
Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.Peer-Reviewed Original Research
2011
Prognosis of Persons with Lyme Borreliosis
Shapiro E, Sood S. Prognosis of Persons with Lyme Borreliosis. 2011, 213-223. DOI: 10.1002/9780470933961.ch11.Peer-Reviewed Original Research
2007
A Critical Appraisal of “Chronic Lyme Disease”
Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.Peer-Reviewed Original ResearchConceptsAcute Lyme diseaseChronic Lyme diseaseLyme diseasePersistent painNeurocognitive symptomsCommon tick-borne infectionSerious public health problemPublic health problemTick-borne infectionsBorrelia burgdorferi sensu strictoBurgdorferi sensu strictoHealth problemsDiseasePainPatientsSymptomsFatigueInfectionDiagnosis
2006
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfection
1996
Lyme Disease in Children in Southeastern Connecticut
Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.Peer-Reviewed Original ResearchConceptsErythema migrans lesionsSingle erythema migrans lesionLyme diseaseErythema migransClinical manifestationsMultiple erythema migrans lesionsCommunity-based cohort studyFacial nerve palsyInitial clinical manifestationPrompt clinical responseEarly Lyme diseasePercent of childrenConventional antimicrobial therapyMultiple erythemaClinical responseCohort studyAseptic meningitisConsecutive patientsMedian ageProspective dataAntimicrobial therapyAntibody testNew episodesPatientsLesions
1994
Lyme Disease
Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. DOI: 10.1542/pir.15.5.167.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLyme diseaseLyme borreliosisCommon vector-borne diseaseIxodes ticksNymphal Ixodes ticksUnexplained arthritisLyme arthritisClinical manifestationsBacterial etiologyClusters of childrenBorrelia burgdoferiMedical attentionSystemic infectionArthritisDistinct entityDiseaseBorrelia burgdorferiPencil pointVector-borne diseasesBorreliosisTicksWood tickPatientsEtiologyYearsLyme Disease
Baltimore R, Shapiro E. Lyme Disease. Pediatrics In Review 1994, 15: 167-173. PMID: 8036192, DOI: 10.1542/pir.15-5-167.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLyme diseaseLyme borreliosisCommon vector-borne diseaseIxodes ticksNymphal Ixodes ticksUnexplained arthritisLyme arthritisClinical manifestationsBacterial etiologyClusters of childrenBorrelia burgdoferiMedical attentionSystemic infectionArthritisDistinct entityDiseaseBorrelia burgdorferiPencil pointVector-borne diseasesBorreliosisTicksWood tickPatientsEtiologyYears
1992
Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers
ANDIMAN W, SILVA T, SHAPIRO E, O'CONNOR T, OLSON B. Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers. The Pediatric Infectious Disease Journal 1992, 11: 436-440. PMID: 1608678, DOI: 10.1097/00006454-199206000-00003.Peer-Reviewed Original ResearchConceptsHIV-1 infectionAntigen testInfected mothersHIV-1Early predictorPositive testPredictive valueHIV-1 infection statusSerial serum samplesLongitudinal cohort studyMonths of lifePositive predictive valueSingle positive testCohort studyInfection statusEnzyme immunoassayFirst monthDiagnostic testsSerum samplesMothersChildrenInfectionMonthsPredictorsPatientsSerologic evidence of active Epstein-barr virus infection in epstein-barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome
Katz B, Berkman A, Shapiro E. Serologic evidence of active Epstein-barr virus infection in epstein-barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome. The Journal Of Pediatrics 1992, 120: 228-232. PMID: 1310507, DOI: 10.1016/s0022-3476(05)80432-9.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLymphocytic interstitial pneumonitisNon-Hodgkin lymphomaCase patientsImmunodeficiency syndromeControl patientsSerologic evidenceEBV infectionInterstitial pneumonitisVirus infectionIndex patientsEpstein-Barr virus-associated lymphoproliferative disorderActive Epstein-Barr virus infectionEpstein-Barr virus infectionHuman immunodeficiency virus (HIV) infectionIndex case patientsActive EBV infectionImmunodeficiency virus infectionCase-control studySpecimens of tissueVirologic evidenceLymphoproliferative disordersSerologic profilePatientsPneumonitis
1991
The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine
Shapiro E, Berg A, Austrian R, Schroeder D, Parcells V, Margolis A, Adair R, Clemens J. The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine. New England Journal Of Medicine 1991, 325: 1453-1460. PMID: 1944423, DOI: 10.1056/nejm199111213252101.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal infectionsPneumococcal polysaccharide vaccinePneumococcal vaccineProtective efficacyPneumococcal infectionCase patientsImmunocompetent patientsPolysaccharide vaccineVaccination historyHospital-based case-control studyPolyvalent pneumococcal polysaccharide vaccineSerious pneumococcal infectionsSite of hospitalizationVaccine protective efficacyPolyvalent pneumococcal vaccineCase-control studyProspective surveillanceRandomized trialsSterile sitesPatientsS. pneumoniaeMedical careStreptococcus pneumoniaeVaccineInfectionMisdiagnosis of Reye's-like Illness
FORSYTH B, SHAPIRO E, HORWITZ R, VISCOLI C, ACAMPORA D. Misdiagnosis of Reye's-like Illness. JAMA Pediatrics 1991, 145: 964-966. PMID: 1877570, DOI: 10.1001/archpedi.1991.02160090014005.Peer-Reviewed Original Research
1989
Blood cultures in the management of febrile outpatients later found to have bacteremia
Alario A, Nelson E, Shapiro E. Blood cultures in the management of febrile outpatients later found to have bacteremia. The Journal Of Pediatrics 1989, 115: 195-199. PMID: 2787855, DOI: 10.1016/s0022-3476(89)80064-2.Peer-Reviewed Original ResearchConceptsBlood culturesPositive blood culturesFebrile outpatientsHaemophilus influenzae type bSerious focal infectionsEpisodes of bacteremiaCases of meningitisInfluenzae type bPersistent bacteremiaPersistent symptomsFocal complicationsFocal infectionOutpatientsStreptococcus pneumoniaeBacteremiaNeisseria meningitidisType BComplicationsPatientsChildrenMeningitisSymptomsInfectionCliniciansPneumoniae
1986
Clinical features as predictors of functional status in children with cystic fibrosis
Katz J, Horwitz R, Dolan T, Shapiro E. Clinical features as predictors of functional status in children with cystic fibrosis. The Journal Of Pediatrics 1986, 108: 352-358. PMID: 3950815, DOI: 10.1016/s0022-3476(86)80872-1.Peer-Reviewed Original ResearchConceptsCystic fibrosisClinical courseClinical featuresGood clinical courseValuable prognostic indicatorPrevious clinical studiesClinical deteriorationGastrointestinal symptomsPrognostic indicatorFunctional statusClinical studiesRespiratory diseaseSurvival rateFibrosisPatientsDiagnosisSubsequent outcomesSubsequent survival ratesChildrenSymptomsOutcomesSubstantial variabilityInitial levelMorbidityYears
1985
Prophylaxis for Bacterial Meningitis
Shapiro E. Prophylaxis for Bacterial Meningitis. Medical Clinics Of North America 1985, 69: 269-280. PMID: 3990434, DOI: 10.1016/s0025-7125(16)31042-2.Peer-Reviewed Original Research
1984
A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infections.
Shapiro E, Clemens J. A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infections. Annals Of Internal Medicine 1984, 101: 325-30. PMID: 6380367, DOI: 10.7326/0003-4819-101-3-325.Peer-Reviewed Original ResearchConceptsIncreased risk of pneumococcal infectionRisk of pneumococcal infectionEfficacy of pneumococcal vaccineSystemic pneumococcal infectionPneumococcal infectionPneumococcal vaccineVaccine protective efficacyIncreased riskProtective efficacyCase-control studyOdds ratioVaccine efficacyHigh riskMatched controlsPatientsInfectionConfounding variablesEfficacyVaccine
1982
Broviac Catheter-Related Bacteremia in Oncology Patients
Shapiro E, Wald E, Nelson K, Spiegelman K. Broviac Catheter-Related Bacteremia in Oncology Patients. JAMA Pediatrics 1982, 136: 679-681. PMID: 7102618, DOI: 10.1001/archpedi.1982.03970440023006.Peer-Reviewed Original ResearchConceptsBroviac cathetersOncology patientsBacteremic episodesCommon initial symptomCatheter-related bacteremiaPediatric oncology patientsCultures of bloodPeripheral veinVascular accessInitial symptomsMalignant tumorsPatientsCatheterKlebsiella pneumoniaeBacteremiaEnterobacter cloacaeStaphylococcus epidermidisStaphylococcus aureusEpisodesInfectionPseudomonas aeruginosaCandida tropicalisChemotherapyFungemiaSymptomsProphylaxis for contacts of patients with meningococcal or Haemophilus influenzae type b disease
SHAPIRO E. Prophylaxis for contacts of patients with meningococcal or Haemophilus influenzae type b disease. The Pediatric Infectious Disease Journal 1982, 1: 132-138. PMID: 6757888, DOI: 10.1097/00006454-198203000-00015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRole of prophylaxisHaemophilus influenzae type b diseaseHaemophilus influenzae type bContacts of patientsCases of meningitisType b diseaseDiagnosis of meningitisInfluenzae type bB diseaseNonepidemic periodsProphylaxisPatientsNeisseria meningitidisPreventive measuresDiseaseType BMeningitisRecommendations of expertsFamily membersSecondary spreadRecent studiesClose contactCurrent understandingIllnessPhysicians