2024
Tick-borne infections in children in North America
Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.Peer-Reviewed Original Research
2007
A Critical Appraisal of “Chronic Lyme Disease”
Feder HM, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, Agger W, Artsob H, Auwaerter P, Dumler J, Bakken J, Bockenstedt L, Green J, Dattwyler R, Munoz J, Nadelman R, Schwartz I, Draper T, McSweegan E, Halperin J, Klempner M, Krause P, Mead P, Morshed M, Porwancher R, Radolf J, Smith R, Sood S, Weinstein A, Wong S, Zemel L. A Critical Appraisal of “Chronic Lyme Disease”. New England Journal Of Medicine 2007, 357: 1422-1430. PMID: 17914043, DOI: 10.1056/nejmra072023.Peer-Reviewed Original ResearchConceptsAcute Lyme diseaseChronic Lyme diseaseLyme diseasePersistent painNeurocognitive symptomsCommon tick-borne infectionSerious public health problemPublic health problemTick-borne infectionsBorrelia burgdorferi sensu strictoBurgdorferi sensu strictoHealth problemsDiseasePainPatientsSymptomsFatigueInfectionDiagnosis
2006
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfection
2004
Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias
Shapiro ED. Case-control studies of the effectiveness of vaccines: validity and assessment of potential bias. The Pediatric Infectious Disease Journal 2004, 23: 127-131. PMID: 14872178, DOI: 10.1097/01.inf.0000109248.32907.1d.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBacterial CapsulesBiasCase-Control StudiesChild, PreschoolConfidence IntervalsFemaleHaemophilus InfectionsHaemophilus influenzae type bHaemophilus VaccinesHumansImmunityImmunization ScheduleInfantMalePolysaccharides, BacterialProbabilityReference ValuesReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeVaccinationConceptsEffectiveness of vaccinesCase-control studyInvasive Hib infectionsHib vaccinePneumococcal infectionHib infectionsInvasive infectionsHaemophilus influenzae type bInvasive pneumococcal infectionsInfluenzae type bMonths of ageIdentical study designOverall 34Study 74S. pneumoniaeStreptococcus pneumoniaeVaccineInfectionStudy designHibType BPneumoniaeValid methodCasesPotential bias
2001
WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS
Juhn Y, Shapiro E, McCarthy P, Freudigman K. WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS. The Pediatric Infectious Disease Journal 2001, 20: 77-79. PMID: 11176573, DOI: 10.1097/00006454-200101000-00016.Peer-Reviewed Original Research
1998
Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children
McCarthy P, Kahn J, Shapiro E, Klig J. Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children. Current Opinion In Pediatrics 1998, 10: 101-116. PMID: 9529649, DOI: 10.1097/00008480-199802000-00021.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCommunicable DiseasesFever of Unknown OriginHerpes SimplexHumansInfantInfant, NewbornPneumonia, MycoplasmaPoliomyelitisPoliovirus Vaccine, InactivatedPolymerase Chain ReactionPractice Guidelines as TopicRespiratory Tract DiseasesStreptococcal InfectionsStreptococcus agalactiaeConceptsInfectious diseasesClinical examinationGroup B Streptococcus ScreeningLower respiratory tract infectionsNeonatal herpes infectionRespiratory tract infectionsPediatric infectious diseasesPediatric office practiceEvaluation of childrenProlonged feverTract infectionsAcute feverHerpes infectionRespiratory infectionsImmunization scheduleUnknown originOffice practiceInfectionDiseaseApparent sourceFeverEugene ShapiroChildrenRecent literaturePaul McCarthyEpidemiology of acute respiratory infections
Shapiro E. Epidemiology of acute respiratory infections. Seminars In Pediatric Infectious Diseases 1998, 9: 31-36. DOI: 10.1016/s1045-1870(98)80048-4.Peer-Reviewed Original ResearchAcute respiratory infectionsYears of ageRespiratory infectionsAnnual mortality rateMortality rateFrequency of ARICase fatality rateMethods of surveillanceCounter medicationsOutpatient settingSerious infectionsChildren 1New vaccinesImportant causeInfectionYoung childrenInfantsChildrenAgeMost studiesAnnual costYearsMedicationsVaccineEpidemiology
1997
Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Kahn J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1997, 9: 105-126. PMID: 9088764, DOI: 10.1097/00008480-199702000-00021.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice settingOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfection
1996
Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1996, 8: 75-93. PMID: 8680522, DOI: 10.1097/00008480-199602000-00017.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfectionChildhood
1995
Office pediatrics
McCarthy P, Bachman D, Shapiro E, Baron M. Office pediatrics. Current Opinion In Pediatrics 1995, 7: 107-125. PMID: 7728195, DOI: 10.1097/00008480-199502000-00020.Commentaries, Editorials and LettersConceptsCommunity-acquired lower respiratory infectionsLower respiratory tract infectionsInfectious diseasesDiarrhea of infancyLower respiratory infectionsRespiratory tract infectionsPediatric office practiceRespiratory syncytial virusHemolytic uremic syndromeEvaluation of childrenDay care centersProlonged feverTract infectionsAcute feverRespiratory infectionsSyncytial virusClinical examinationCare centerEnterohemorrhagic Escherichia coliStreptococcus pneumoniaeUnknown originOffice settingOffice practiceInfectionAntimicrobial drugs
1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferiOutcome of children with occult bacteremia caused by Haemophilus influenzae type b
KORONES D, MARSHALL G, SHAPIRO E. Outcome of children with occult bacteremia caused by Haemophilus influenzae type b. The Pediatric Infectious Disease Journal 1992, 11: 516-520. PMID: 1528640, DOI: 10.1097/00006454-199207000-00002.Peer-Reviewed Original ResearchConceptsHaemophilus influenzae type bOutcome of childrenInfluenzae type bOccult bacteremiaHib bacteremiaYale-New Haven HospitalSerious focal infectionsType BClinical courseMedian ageHib infectionsChildren's HospitalSerious infectionsHealthy childrenMedical recordsFocal infectionBacteremiaHospitalInfectionChildrenOutpatientsSuch antimicrobialsOutcomesBetter definitionAntimicrobialsPredictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers
ANDIMAN W, SILVA T, SHAPIRO E, O'CONNOR T, OLSON B. Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers. The Pediatric Infectious Disease Journal 1992, 11: 436-440. PMID: 1608678, DOI: 10.1097/00006454-199206000-00003.Peer-Reviewed Original ResearchConceptsHIV-1 infectionAntigen testInfected mothersHIV-1Early predictorPositive testPredictive valueHIV-1 infection statusSerial serum samplesLongitudinal cohort studyMonths of lifePositive predictive valueSingle positive testCohort studyInfection statusEnzyme immunoassayFirst monthDiagnostic testsSerum samplesMothersChildrenInfectionMonthsPredictorsPatients
1991
The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine
Shapiro E, Berg A, Austrian R, Schroeder D, Parcells V, Margolis A, Adair R, Clemens J. The Protective Efficacy of Polyvalent Pneumococcal Polysaccharide Vaccine. New England Journal Of Medicine 1991, 325: 1453-1460. PMID: 1944423, DOI: 10.1056/nejm199111213252101.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal infectionsPneumococcal polysaccharide vaccinePneumococcal vaccineProtective efficacyPneumococcal infectionCase patientsImmunocompetent patientsPolysaccharide vaccineVaccination historyHospital-based case-control studyPolyvalent pneumococcal polysaccharide vaccineSerious pneumococcal infectionsSite of hospitalizationVaccine protective efficacyPolyvalent pneumococcal vaccineCase-control studyProspective surveillanceRandomized trialsSterile sitesPatientsS. pneumoniaeMedical careStreptococcus pneumoniaeVaccineInfection
1990
New Vaccines Against Haemophilus Influenzae Type b
Shapiro E. New Vaccines Against Haemophilus Influenzae Type b. Pediatric Clinics Of North America 1990, 37: 567-583. PMID: 2190140, DOI: 10.1016/s0031-3955(16)36905-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Blood cultures in the management of febrile outpatients later found to have bacteremia
Alario A, Nelson E, Shapiro E. Blood cultures in the management of febrile outpatients later found to have bacteremia. The Journal Of Pediatrics 1989, 115: 195-199. PMID: 2787855, DOI: 10.1016/s0022-3476(89)80064-2.Peer-Reviewed Original ResearchConceptsBlood culturesPositive blood culturesFebrile outpatientsHaemophilus influenzae type bSerious focal infectionsEpisodes of bacteremiaCases of meningitisInfluenzae type bPersistent bacteremiaPersistent symptomsFocal complicationsFocal infectionOutpatientsStreptococcus pneumoniaeBacteremiaNeisseria meningitidisType BComplicationsPatientsChildrenMeningitisSymptomsInfectionCliniciansPneumoniae
1986
Does breast-feeding protect against infections in infants less than 3 months of age?
Leventhal J, Shapiro E, Aten C, Berg A, Egerter S. Does breast-feeding protect against infections in infants less than 3 months of age? Pediatrics 1986, 78: 896-903. PMID: 3093969, DOI: 10.1542/peds.78.5.896.Peer-Reviewed Original ResearchConceptsCase-control pairsSurveillance biasOdds ratioProtective effectYale-New Haven HospitalBreast-feeding protectsPotential surveillance biasTime of hospitalizationSeverity of illnessBreast-fed infantsCase-control studyApparent protective effectMonths of ageLogistic regression modelsDays of ageMild illnessInfectious illnessPotential confoundersHealthy childrenMedical conditionsStratified resultsSerious illnessInfantsIllnessInfectionStudies of Breast-feeding and Infections: How Good Is the Evidence?
Bauchner H, Leventhal J, Shapiro E. Studies of Breast-feeding and Infections: How Good Is the Evidence? JAMA 1986, 256: 887-892. DOI: 10.1001/jama.1986.03380070093026.Peer-Reviewed Original Research
1985
Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children.
Kovatch A, Wald E, Albo V, Prin W, Orlando S, Wollman M, Phebus C, Shapiro E. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985, 76: 754-60. PMID: 3903647, DOI: 10.1542/peds.76.5.754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Infective AgentsAntineoplastic AgentsBacterial InfectionsChildChild, PreschoolClinical Trials as TopicDouble-Blind MethodDrug CombinationsDrug Therapy, CombinationFemaleHumansInfantLeukemia, LymphoidLeukemia, Myeloid, AcuteMaleMicrobial Sensitivity TestsRandom AllocationSulfamethoxazoleTrimethoprimTrimethoprim, Sulfamethoxazole Drug CombinationConceptsTrimethoprim/sulfamethoxazoleOral trimethoprim/sulfamethoxazoleTrimethoprim/sulfamethoxazole groupFebrile episodesBacterial infectionsAcute leukemiaSolid tumorsPlacebo-controlled studyFrequency of bacteremiaInduction phaseInvasive fungal infectionsLife-table analysisGranulocytopenic childrenInduction chemotherapyReceiving placeboIntensive chemotherapyPlacebo groupOral thrushMean durationChemotherapyBacteremiaFungal infectionsOverall riskCancer chemotherapyInfectionProphylaxis for Bacterial Meningitis
Shapiro E. Prophylaxis for Bacterial Meningitis. Medical Clinics Of North America 1985, 69: 269-280. PMID: 3990434, DOI: 10.1016/s0025-7125(16)31042-2.Peer-Reviewed Original Research