1996
Lyme Disease in Children in Southeastern Connecticut
Gerber M, Shapiro E, Burke G, Parcells V, Bell G. Lyme Disease in Children in Southeastern Connecticut. New England Journal Of Medicine 1996, 335: 1270-1274. PMID: 8857006, DOI: 10.1056/nejm199610243351703.Peer-Reviewed Original ResearchConceptsErythema migrans lesionsSingle erythema migrans lesionLyme diseaseErythema migransClinical manifestationsMultiple erythema migrans lesionsCommunity-based cohort studyFacial nerve palsyInitial clinical manifestationPrompt clinical responseEarly Lyme diseasePercent of childrenConventional antimicrobial therapyMultiple erythemaClinical responseCohort studyAseptic meningitisConsecutive patientsMedian ageProspective dataAntimicrobial therapyAntibody testNew episodesPatientsLesions
1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferi