2024
The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.Peer-Reviewed Original ResearchRadiologically isolated syndromeSpinal MRIDiagnostic workup of childrenMultiple sclerosisWorkup of childrenFisher's exact testMultivariate logistic regressionInternational longitudinal studyDiagnostic workupConsensus guidelinesExact testMS riskLogistic regressionConclusionsYoung childrenCSFBackgroundCerebrospinal fluidMRIPre-2017Longitudinal studySyndromeRadiologyChildrenAgeSexRiskTick-borne infections in children in North America
Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.Peer-Reviewed Original Research
2001
The Effectiveness of the Varicella Vaccine in Clinical Practice
Vázquez M, LaRussa P, Gershon A, Steinberg S, Freudigman K, Shapiro E. The Effectiveness of the Varicella Vaccine in Clinical Practice. New England Journal Of Medicine 2001, 344: 955-960. PMID: 11274621, DOI: 10.1056/nejm200103293441302.Peer-Reviewed Original ResearchConceptsVaricella-zoster virusVaricella vaccinePolymerase chain reactionMild diseasePediatric practiceClinical practicePositive PCR testCase-control studyConditional logistic regressionPotential casesUnvaccinated childrenPotential confoundersActive surveillanceSevere diseaseChickenpoxDay 3VaccineLogistic regressionPCR testDiseaseChain reactionChildrenResearch assistantsIllnessVirusWILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS
Juhn Y, Shapiro E, McCarthy P, Freudigman K. WILLINGNESS OF DIRECTORS OF CHILD CARE CENTERS TO CARE FOR CHILDREN WITH CHRONIC INFECTIONS. The Pediatric Infectious Disease Journal 2001, 20: 77-79. PMID: 11176573, DOI: 10.1097/00006454-200101000-00016.Peer-Reviewed Original Research
2000
Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus
King J, Borkowsky W, Mahidhara N, Madore D, Shapiro E, Rutstein R, Tan T, Farley J, Dankner W, Nachman S, Simoes E, Flynn P, Clemens J, Hamilton R. Group-Specific Antibody Levels Surrounding Invasive Pneumococcal Illness in Children Infected with Human Immunodeficiency Virus. The Journal Of Infectious Diseases 2000, 181: 1817-1821. PMID: 10823792, DOI: 10.1086/315441.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAntibody levelsSerum samplesPneumococcal illnessImmunodeficiency virusPneumococcal antibody levelsGeometric mean levelsAntibody valuesPneumococcal serotypesIgG antibodiesGroup 4Mean levelsSeroresponsesIllnessChildrenWeeksSerotypesVirusLevelsSerorespondersELISAAntibodies
1998
Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children
McCarthy P, Kahn J, Shapiro E, Klig J. Fever without apparent source on clinical examination, Infectious diseases, and Lower respiratory infections in children. Current Opinion In Pediatrics 1998, 10: 101-116. PMID: 9529649, DOI: 10.1097/00008480-199802000-00021.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCommunicable DiseasesFever of Unknown OriginHerpes SimplexHumansInfantInfant, NewbornPneumonia, MycoplasmaPoliomyelitisPoliovirus Vaccine, InactivatedPolymerase Chain ReactionPractice Guidelines as TopicRespiratory Tract DiseasesStreptococcal InfectionsStreptococcus agalactiaeConceptsInfectious diseasesClinical examinationGroup B Streptococcus ScreeningLower respiratory tract infectionsNeonatal herpes infectionRespiratory tract infectionsPediatric infectious diseasesPediatric office practiceEvaluation of childrenProlonged feverTract infectionsAcute feverHerpes infectionRespiratory infectionsImmunization scheduleUnknown originOffice practiceInfectionDiseaseApparent sourceFeverEugene ShapiroChildrenRecent literaturePaul McCarthyEpidemiology of acute respiratory infections
Shapiro E. Epidemiology of acute respiratory infections. Seminars In Pediatric Infectious Diseases 1998, 9: 31-36. DOI: 10.1016/s1045-1870(98)80048-4.Peer-Reviewed Original ResearchAcute respiratory infectionsYears of ageRespiratory infectionsAnnual mortality rateMortality rateFrequency of ARICase fatality rateMethods of surveillanceCounter medicationsOutpatient settingSerious infectionsChildren 1New vaccinesImportant causeInfectionYoung childrenInfantsChildrenAgeMost studiesAnnual costYearsMedicationsVaccineEpidemiology
1997
Vaccination for Varicella—Just Do It!
Shapiro E, LaRussa P. Vaccination for Varicella—Just Do It! JAMA 1997, 278: 1529-1530. DOI: 10.1001/jama.1997.03550180079042.Commentaries, Editorials and LettersConceptsVaricella vaccineVaccine-induced immunity wanesStrategy of immunizationDuration of protectionMonths of agePublic health servicesImmune childrenImmunization PracticesImmunity wanesUS FoodDrug AdministrationSusceptible adultsSusceptible individualsInfants 12Health servicesAmerican AcademyInfectious diseasesVaccineVaricellaAdvisory CommitteeAdultsConsiderable controversyChildrenVaccineesMorbidityLyme Disease in Children
Shapiro E, Seltzer E. Lyme Disease in Children. Seminars In Neurology 1997, 17: 39-44. PMID: 9166958, DOI: 10.1055/s-2008-1040911.ChaptersFever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Kahn J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1997, 9: 105-126. PMID: 9088764, DOI: 10.1097/00008480-199702000-00021.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice settingOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfection
1996
Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood
McCarthy P, Klig J, Shapiro E, Baron M. Fever without apparent source on clinical examination, Lower respiratory infections in children, Other infectious diseases, and Acute gastroenteritis and diarrhea of infancy and early childhood. Current Opinion In Pediatrics 1996, 8: 75-93. PMID: 8680522, DOI: 10.1097/00008480-199602000-00017.Commentaries, Editorials and LettersConceptsDiarrhea of infancyInfectious diseasesClinical examinationLower respiratory tract infectionsRespiratory tract infectionsPediatric office practiceEvaluation of childrenEarly childhoodProlonged feverTract infectionsAcute feverRespiratory infectionsAcute gastroenteritisUnknown originOffice practiceDiseaseRecent literatureApparent sourceDiarrheaFeverEugene ShapiroChildrenGastroenteritisInfectionChildhood
1993
Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1
Ikeda M, Andiman W, Mezger J, Shapiro E, Miller G. Quantitative leukoviremia and immune complex-dissociated antigenemia as predictors of infection status in children born to mothers infected with human immunodeficiency virus type 1. The Journal Of Pediatrics 1993, 122: 524-531. PMID: 8463895, DOI: 10.1016/s0022-3476(05)83530-9.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1Infection statusCulture resultsHIV-1-infected mothersType 1Peripheral blood mononuclear cellsSerum antigen testHIV-1 antigensBlood mononuclear cellsPositive culture resultsNegative culture resultsSeronegative donorsInfected childrenReactive antibodiesAntigen testMononuclear cellsClinical criteriaHIV-1Immune complexesCocultureChildrenPositive resultsAntigen
1992
A Prospective Study of Recurrent Febrile Seizures
Berg A, Shinnar S, Hauser W, Alemany M, Shapiro E, Salomon M, Crain E. A Prospective Study of Recurrent Febrile Seizures. New England Journal Of Medicine 1992, 327: 1122-1127. PMID: 1528207, DOI: 10.1056/nejm199210153271603.Peer-Reviewed Original ResearchConceptsRisk of recurrenceRecurrent febrile seizuresFebrile seizuresProspective studyFamily historyFirst febrile seizureDuration of feverPredictors of recurrenceComplex febrile seizuresInitial febrile seizurePediatric emergency departmentInitial seizureEmergency departmentMedical recordsNeurodevelopmental abnormalitiesCumulative riskRecurrenceFeverSeizuresDegree of increaseDegrees FChildrenRiskShort durationMonthsOutcome of children with occult bacteremia caused by Haemophilus influenzae type b
KORONES D, MARSHALL G, SHAPIRO E. Outcome of children with occult bacteremia caused by Haemophilus influenzae type b. The Pediatric Infectious Disease Journal 1992, 11: 516-520. PMID: 1528640, DOI: 10.1097/00006454-199207000-00002.Peer-Reviewed Original ResearchConceptsHaemophilus influenzae type bOutcome of childrenInfluenzae type bOccult bacteremiaHib bacteremiaYale-New Haven HospitalSerious focal infectionsType BClinical courseMedian ageHib infectionsChildren's HospitalSerious infectionsHealthy childrenMedical recordsFocal infectionBacteremiaHospitalInfectionChildrenOutpatientsSuch antimicrobialsOutcomesBetter definitionAntimicrobialsPredictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers
ANDIMAN W, SILVA T, SHAPIRO E, O'CONNOR T, OLSON B. Predictive value of the human immunodeficiency virus 1 antigen test in children born to infected mothers. The Pediatric Infectious Disease Journal 1992, 11: 436-440. PMID: 1608678, DOI: 10.1097/00006454-199206000-00003.Peer-Reviewed Original ResearchConceptsHIV-1 infectionAntigen testInfected mothersHIV-1Early predictorPositive testPredictive valueHIV-1 infection statusSerial serum samplesLongitudinal cohort studyMonths of lifePositive predictive valueSingle positive testCohort studyInfection statusEnzyme immunoassayFirst monthDiagnostic testsSerum samplesMothersChildrenInfectionMonthsPredictorsPatients
1990
New Vaccines Against Haemophilus Influenzae Type b
Shapiro E. New Vaccines Against Haemophilus Influenzae Type b. Pediatric Clinics Of North America 1990, 37: 567-583. PMID: 2190140, DOI: 10.1016/s0031-3955(16)36905-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Blood cultures in the management of febrile outpatients later found to have bacteremia
Alario A, Nelson E, Shapiro E. Blood cultures in the management of febrile outpatients later found to have bacteremia. The Journal Of Pediatrics 1989, 115: 195-199. PMID: 2787855, DOI: 10.1016/s0022-3476(89)80064-2.Peer-Reviewed Original ResearchConceptsBlood culturesPositive blood culturesFebrile outpatientsHaemophilus influenzae type bSerious focal infectionsEpisodes of bacteremiaCases of meningitisInfluenzae type bPersistent bacteremiaPersistent symptomsFocal complicationsFocal infectionOutpatientsStreptococcus pneumoniaeBacteremiaNeisseria meningitidisType BComplicationsPatientsChildrenMeningitisSymptomsInfectionCliniciansPneumoniae
1987
A COMMUNITY-BASED CASE-CONTROL STUDY OF THE ASSOCIATION BETWEEN THE ATTENDANDCE OF GROUP DAY CARE AND DISEASE DUE TO HAEMOPHILUS INFLUNZAE TYPE B (Hib)
Shapiro E. A COMMUNITY-BASED CASE-CONTROL STUDY OF THE ASSOCIATION BETWEEN THE ATTENDANDCE OF GROUP DAY CARE AND DISEASE DUE TO HAEMOPHILUS INFLUNZAE TYPE B (Hib). Pediatric Research 1987, 21: 262-262. DOI: 10.1203/00006450-198704010-00569.Peer-Reviewed Original Research
1986
Risk factors for development of bacterial meningitis among children with occult bacteremia
Shapiro E, Aaron N, Wald E, Chiponis D. Risk factors for development of bacterial meningitis among children with occult bacteremia. The Journal Of Pediatrics 1986, 109: 15-19. PMID: 3088242, DOI: 10.1016/s0022-3476(86)80564-9.Peer-Reviewed Original ResearchConceptsOccult bacteremiaBacterial meningitisInfluenzae type bClinical characteristicsInitial visitLumbar punctureRisk factorsRelative riskHaemophilus influenzae type bYale-New Haven HospitalH. influenzae type bType BChildren's HospitalPossible confounding effectsMeningitisBacteremiaEstimates of riskS. pneumoniaeStreptococcus pneumoniaeLogistic regressionN. meningitidisNeisseria meningitidisHospitalChildrenRiskClinical features as predictors of functional status in children with cystic fibrosis
Katz J, Horwitz R, Dolan T, Shapiro E. Clinical features as predictors of functional status in children with cystic fibrosis. The Journal Of Pediatrics 1986, 108: 352-358. PMID: 3950815, DOI: 10.1016/s0022-3476(86)80872-1.Peer-Reviewed Original ResearchConceptsCystic fibrosisClinical courseClinical featuresGood clinical courseValuable prognostic indicatorPrevious clinical studiesClinical deteriorationGastrointestinal symptomsPrognostic indicatorFunctional statusClinical studiesRespiratory diseaseSurvival rateFibrosisPatientsDiagnosisSubsequent outcomesSubsequent survival ratesChildrenSymptomsOutcomesSubstantial variabilityInitial levelMorbidityYears