2024
Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability
Friligkou E, Koller D, Pathak G, Miller E, Lampert R, Stein M, Polimanti R. Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability. Molecular Psychiatry 2024, 1-7. PMID: 39558002, DOI: 10.1038/s41380-024-02836-7.Peer-Reviewed Original ResearchPolygenic risk scoresMendelian randomizationReuptake inhibitorsOne-sample Mendelian randomizationElectronic health record dataOne-sample MRHealth record dataMillion Veteran ProgramPotential causal effectSerotonin reuptake inhibitorsNorepinephrine reuptake inhibitorsGenome-wide association studiesEffects of anxietyImpact of anxietyWearable device dataUK BiobankVeteran ProgramAntidepressant prescriptionsAnxiety disordersAntidepressant medicationAntidepressant useAntidepressant exposureTricyclic antidepressantsPRS-CSRecord data
2023
T4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS
Friligkou E, Koller D, Pathak G, Miller E, Lampert R, Stein M, Polimanti R. T4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS. European Neuropsychopharmacology 2023, 75: s164. DOI: 10.1016/j.euroneuro.2023.08.294.Peer-Reviewed Original ResearchHeart rate variabilityAverage RR intervalElectronic health recordsPolygenic risk scoresReuptake inhibitorsAntidepressant classesAntidepressant useSelective serotonin reuptake inhibitorsAntidepressant substancesMendelian randomizationRate variabilityRR intervalsCo-existing health conditionsNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsAvailable electronic health recordsBackground Anxiety disordersCardiovascular comorbiditiesAntidepressant prescriptionsOne-sample Mendelian randomizationSerotonin antagonistsTricyclic antidepressantsMajor depressionMillion Veteran ProgramObservational nature