2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
2022
Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.Peer-Reviewed Original ResearchConceptsRight heart functionDeficient micePulmonary arteryHeart functionCompromised right ventricular functionFibulin-5 deficient micePulmonary arterial structureRight ventricular functionVentilation-perfusion relationshipsElastic fiber contentElastic fibersFiber dysfunctionLung compliancePulmonary healthVentricular functionCardiopulmonary functionAlveolar disruptionPulmonary pathologyLung parenchymaMurine modelMouse modelArterial structureHistological quantificationElastic laminaRight circulation
2019
Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
Ryu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.Peer-Reviewed Original ResearchConceptsExtrapulmonary diseaseMitochondrial DNAExtracellular mtDNABAL fluidAlpha-1 antitrypsin deficiencyPlasma mitochondrial DNAPlasma of patientsAfrican AmericansExtrapulmonary sarcoidosisSarcoidosis cohortSarcoidosis subjectsScadding stageAfrican American descentClinical featuresClinical findingsGranulomatous diseaseHealthy controlsAntitrypsin deficiencyGenomic researchHigher oddsSarcoidosisAggressive phenotypeMechanistic basisDiseaseTherapeutic insightsPulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report
Hakim A, Bazan IS, Sanogo ML, Manning EP, Pollak JS, Chupp GL. Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report. BMC Pulmonary Medicine 2019, 19: 34. PMID: 30736787, PMCID: PMC6368789, DOI: 10.1186/s12890-019-0797-7.Peer-Reviewed Original ResearchConceptsPulmonary artery pseudoaneurysmArtery pseudoaneurysmMassive hemoptysisArtery angiographyE syndromeSelective pulmonary artery angiographyRare primary immunodeficiency disorderBronchial artery angiographyImmunoglobulin E titersRecurrent skin abscessesRecurrent respiratory infectionsAllergic bronchopulmonary aspergillosisHyperimmunoglobulin E syndromePulmonary artery angiographyPrimary immunodeficiency disordersRecurrent massive hemoptysisBronchopulmonary aspergillosisActive hemorrhageBronchial arteryRespiratory infectionsTranscatheter embolizationCase presentationWeSkin abscessesCase reportImmunodeficiency disorders
2018
Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection
Manning EP, Mishall PL, Weidmann MD, Flax H, Lan S, Erlich M, Burton WB, Olson TR, Downie SA. Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection. Anatomical Sciences Education 2018, 11: 605-612. PMID: 29603672, PMCID: PMC6165707, DOI: 10.1002/ase.1785.Peer-Reviewed Original ResearchConceptsThird-year clerkshipMedical studentsStudent confidenceFirst-year medical studentsMedical student comfortProlonged opportunityLack of instructionAnatomy dissection laboratoryStudent behaviorStudents' attitudesStudent comfortDissection laboratoryProcedural skillsStudentsClerkshipFirst-time exposureProlonged introductionPatient interactionsCadaver dissectionLow-stress environmentConfidenceOpportunitiesInstructionSkillsAttitudes