COMPUTATIONAL CHARACTERIZATION OF MUTATIONS IN CARDIAC TROPONIN T KNOWN TO CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHY
Guinto PJ, Manning EP, Schwartz SD, Tardiff JC. COMPUTATIONAL CHARACTERIZATION OF MUTATIONS IN CARDIAC TROPONIN T KNOWN TO CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. Journal Of Computational Biophysics And Chemistry 2007, 6: 413-419. PMID: 26500385, PMCID: PMC4617307, DOI: 10.1142/s0219633607003271.Peer-Reviewed Original ResearchNormal protein-protein interactionsHelical regionProtein-protein interactionsFHC mutationsTail domainWild typeResidue 105Helical turnCentral modulatorThin filament regulationFunctional implicationsPoint mutationsMutation sitesFamilial hypertrophic cardiomyopathyRamachandran plotMutationsResiduesStructural dataHelixThin filamentsMolecular dynamics simulationsMutantsMyofilament activationTnt1Computational characterization