2007
A connector of two-component regulatory systems promotes signal amplification and persistence of expression
Kato A, Mitrophanov AY, Groisman EA. A connector of two-component regulatory systems promotes signal amplification and persistence of expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12063-12068. PMID: 17615238, PMCID: PMC1924540, DOI: 10.1073/pnas.0704462104.Peer-Reviewed Original ResearchConceptsTwo-component regulatory systemBacterial signal transductionRegulatory systemPersistence of expressionSignal transductionGene transcriptionRegulatory architectureSmall proteinsSalmonella entericaPathwayFunctional characteristicsPmrDExpressionFunctional propertiesPhoP.AmplificationTranscriptionSignal amplificationTransductionGenesDominant formOrganismsProteinPersistenceEnterica
2005
Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica
Zwir I, Shin D, Kato A, Nishino K, Latifi T, Solomon F, Hare JM, Huang H, Groisman EA. Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 2862-2867. PMID: 15703297, PMCID: PMC548500, DOI: 10.1073/pnas.0408238102.Peer-Reviewed Original ResearchConceptsRegulatory networksEnteric bacteria Escherichia coliDistinct regulatory networksEscherichia coliPhoP/PhoQTwo-component systemSalmonella entericaCoregulated promotersPhoP proteinGenomic approachesPhoP regulonPromoter featuresRegulatory featuresGene transcriptionGene expressionBacteria Escherichia coliRegulatory systemGenesMultiple mechanismsColiResistance determinantsEntericaRegulonPhoQTranscription
2002
Conflicting needs for a Salmonella hypervirulence gene in host and non‐host environments
Mouslim C, Hilbert F, Huang H, Groisman EA. Conflicting needs for a Salmonella hypervirulence gene in host and non‐host environments. Molecular Microbiology 2002, 45: 1019-1027. PMID: 12180921, DOI: 10.1046/j.1365-2958.2002.03070.x.Peer-Reviewed Original ResearchConceptsSole carbon sourceD-Ala-D-Ala dipeptidaseNon-host environmentsNutrient-poor conditionsPathogen Salmonella entericaCarbon sourceWild-type SalmonellaPathogen fitnessFaster growth rateGenesInfected hostHypervirulence genesMutantsInnate immunitySalmonella entericaDipeptidase activityGrowth rateHostInactivationPhenotypeFitnessDipeptidasePathogensSalmonellaEnterica
2000
Molecular mechanisms of Salmonella pathogenesis
Groisman EA, Mouslim C. Molecular mechanisms of Salmonella pathogenesis. Current Opinion In Infectious Diseases 2000, 13: 519-522. PMID: 11964823, DOI: 10.1097/00001432-200010000-00014.Peer-Reviewed Original Research
1998
Seeking the genetic basis of phenotypic differences among bacterial species
Ochman H, Groisman E. Seeking the genetic basis of phenotypic differences among bacterial species. 1998, 221-235. DOI: 10.1007/978-3-0348-8948-3_12.Peer-Reviewed Original ResearchEnteric bacteria Escherichia coliBacterial speciesSpecies-specific genesSpecies-specific charactersGene complementSole carbon sourceDNA regionsPhenotypic charactersGenetic basisAllelic variationBacteria Escherichia coliPhenotypic differencesEscherichia coliSpeciesSalmonella entericaCarbon sourceGenesMicrobesCertain compoundsColiObserved differencesPhysiologySequenceEntericaCharacter