2016
DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching
Powell JT, Akhuetie‐Oni B, Zhang Z, Lin C. DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching. Angewandte Chemie International Edition 2016, 55: 11412-11416. PMID: 27527591, PMCID: PMC5019031, DOI: 10.1002/anie.201604621.Peer-Reviewed Original ResearchConceptsRotaxane assemblySupramolecular assembliesAssembly routeStructure switchingStructural switchingRotaxanesFunctional nanodevicesUnique structureBuilding blocksMacrocyclesDNA hybridizationElectron microscopyFinal productMultistep assemblyAssemblySynthesisStructural integrityHereinNanodevicesTranslational motionMicroscopySecond mechanismFirst mechanismRouteElectrophoresis
2008
Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity
Lin C, Nangreave JK, Li Z, Liu Y, Yan H. Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity. Nanomedicine 2008, 3: 521-528. PMID: 18694314, DOI: 10.2217/17435889.3.4.521.Peer-Reviewed Original ResearchConceptsHybridization chain reactionSignal amplificationSelf-assembled DNAMultiplexed biosensingFluorescence enhancementNanomedical applicationsSensitive detectionDetection probeConfocal fluorescence microscopySignal amplifierImprovement of sensitivityDetection sensitivityOrders of magnitudeEnhanced sensitivityBiosensorBiosensingFluorescence microscopyNanoarraysSuccessful detectionReactionMicroscopyVersatilityDetection targetProbeDetection