2017
Zika virus targets blood monocytes
Jurado KA, Iwasaki A. Zika virus targets blood monocytes. Nature Microbiology 2017, 2: 1460-1461. PMID: 29070824, DOI: 10.1038/s41564-017-0049-7.Peer-Reviewed Original ResearchSensing Self and Foreign Circular RNAs by Intron Identity
Chen YG, Kim MV, Chen X, Batista PJ, Aoyama S, Wilusz JE, Iwasaki A, Chang HY. Sensing Self and Foreign Circular RNAs by Intron Identity. Molecular Cell 2017, 67: 228-238.e5. PMID: 28625551, PMCID: PMC5610545, DOI: 10.1016/j.molcel.2017.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDEAD Box Protein 58Encephalitis Virus, Venezuelan EquineEncephalomyelitis, Venezuelan EquineHEK293 CellsHeLa CellsHost-Pathogen InteractionsHumansImmune ToleranceImmunity, InnateIntronsMiceNucleic Acid ConformationProtein BindingRAW 264.7 CellsReceptors, ImmunologicRNARNA Processing, Post-TranscriptionalRNA-Binding ProteinsRNA, CircularRNA, MessengerSpliceosomesTransfectionConceptsCircular RNAsInnate immunity genesMammalian transcriptionDiverse RNACytoplasmic fociHuman circRNAsMammalian cellsImmunity genesEndogenous splicingHuman intronsInnate immune sensingPrimary sequenceCircRNA sequenceRNA structureCircRNAsUnknown functionIntronsRNASensor RIGImmune sensingInnate immunitySelf-nonself discriminationPotent inductionSequenceBiogenesis
2008
Dendritic cells and macrophages in the genitourinary tract
Iijima N, Thompson J, Iwasaki A. Dendritic cells and macrophages in the genitourinary tract. Mucosal Immunology 2008, 1: 451-459. PMID: 19079212, PMCID: PMC2684461, DOI: 10.1038/mi.2008.57.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritic CellsGonadal Steroid HormonesHumansImmune ToleranceMacrophagesSexually Transmitted DiseasesUrogenital SystemConceptsAntigen-presenting cellsDendritic cellsGenitourinary tractGU tractUnderstanding of DCsSubsets of DCsImmune defenseFemale genital mucosaInnate immune defenseGenital mucosaMaternal toleranceSex hormonesAdaptive immunityReproductive functionMacrophagesTractNumerous agentsSTIsImportant reproductive functionsCellsDivergent rolesMucosaFetusesInfectionHormone
2005
Intestinal epithelial barrier and mucosal immunity
Sato A, Iwasaki A. Intestinal epithelial barrier and mucosal immunity. Cellular And Molecular Life Sciences 2005, 62: 1333. PMID: 15971108, DOI: 10.1007/s00018-005-5037-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritic CellsHumansImmune ToleranceImmunity, MucosalImmunoglobulin AIntestinal MucosaPeyer's PatchesT-LymphocytesConceptsDendritic cellsMucosal immunityPeyer's patchesMajor inductive siteMucosal dendritic cellsPP dendritic cellsResident dendritic cellsMucosal immune systemIntestinal epithelial barrierFood antigensInductive sitesGastrointestinal mucosaT cellsImmune inductionImmune responseRecent studiesEpithelial barrierImmune systemCommensal microbesSmall intestineA responsesInfectious pathogensImmunityAntigenInduction
2004
Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity
FLEETON M, CONTRACTOR N, LEON F, HE J, WETZEL D, DERMODY T, IWASAKI A, KELSALL B. Involvement of Dendritic Cell Subsets in the Induction of Oral Tolerance and Immunity. Annals Of The New York Academy Of Sciences 2004, 1029: 60-65. PMID: 15681744, DOI: 10.1196/annals.1309.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritic CellsImmune ToleranceImmunity, MucosalMicePeyer's PatchesReoviridae InfectionsT-LymphocytesConceptsSubepithelial dome regionDendritic cellsApoptotic epithelial cellsDC maturationEpithelial cellsOral administrationT cellsImmune responsePP follicle-associated epitheliumSystemic antiviral immune responsesDendritic cell subsetsPlasmacytoid dendritic cellsCross-present antigensRegulatory T cellsInduction of immunityB cell responsesAntiviral immune responseActive viral infectionFollicle-associated epitheliumMurine Peyer's patchesDC infectionDC subsetsOral antigenDC populationsOral tolerance