Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchNeuroactive steroidsMenstrual cycleNervous systemEstrous cycleRat estrous cycleNeuroactive steroid levelsLevels of pregnenoloneSex steroid hormone levelsOvarian cycleRegulation of nervous functionsPeripheral nervous systemSteroid hormone levelsPsychiatric disordersSteroid patternBrain regionsHormone levelsTherapeutic consequencesNeuropathological eventsPeripheral nervesSteroid levelsNeuroprotective agentsNervous functionSteroidsPhysiological regulationProgesteroneSex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original ResearchSex chromosome complementChromosome complementGenotype mouse modelNeuroactive steroid levelsNeuroactive steroidsMouse modelSteroid levelsSex chromosomesSRY geneSexual dimorphism levelsSex determinationContribution of sex chromosome complementTissue-specific actionsGonadsLiquid chromatography-tandem mass spectrometryGonadal hormonesChromatography-tandem mass spectrometryNeuroprotective actionSteroidsSexual featuresLevel regulationNervous systemSex-specificGenotypesComplement