Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLuis Garcia-Segura, PhD
About
Research
Publications
2026
Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery
Gallagher L, Dominiczak A, Garcia‐Segura L, Harada N, Hutchison J, Mullin J, Graham D, O'Shaughnessy P, Carswell H. Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery. Neuroprotection 2026, 4: 143-156. PMID: 42368197, PMCID: PMC13306120, DOI: 10.1002/nep3.70033.Peer-Reviewed Original Research
2025
Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone. Biomedicine & Pharmacotherapy 2025, 190: 118419. PMID: 40779885, DOI: 10.1016/j.biopha.2025.118419.Peer-Reviewed Original ResearchRole of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults
Ortolá R, Sotos‐Prieto M, Carballo‐Casla A, Cabello‐Plan S, Koni A, Mustieles V, García‐Segura L, Artalejo A, Rodríguez‐Artalejo F, García‐Esquinas E. Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults. European Journal Of Pain 2025, 29: e70014. PMID: 40222813, PMCID: PMC11994381, DOI: 10.1002/ejp.70014.Peer-Reviewed Original Research
2024
Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex
Pinto-Benito D, Bautista-Abad A, Lagunas N, Ontiveros N, Ganchala D, Garcia-Segura L, Arevalo M, Grassi D. Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167532. PMID: 39366643, DOI: 10.1016/j.bbadis.2024.167532.Peer-Reviewed Original ResearchNeuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchAging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Bautista-Abad Á, García-Magro N, Pinto-Benito D, Cáceres-Pajuelo J, Alises C, Ganchala D, Lagunas N, Negredo P, García-Segura L, Arevalo M, Grassi D. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input. GeroScience 2024, 46: 6459-6472. PMID: 38954130, PMCID: PMC11493896, DOI: 10.1007/s11357-024-01268-z.Peer-Reviewed Original ResearchGonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Gonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106520. PMID: 38614433, DOI: 10.1016/j.jsbmb.2024.106520.Peer-Reviewed Original ResearchSex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original Research
2021
Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis
Mancino D, Lima A, Roig P, Segura L, De Nicola A, Garay L. Tibolone restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis. Journal Of Neuroendocrinology 2021, 34: e13078. PMID: 34961984, DOI: 10.1111/jne.13078.Peer-Reviewed Original Research
2007
La reconversión del Instituto Cajal
Borrell J, Ferrús A, Segura L. La reconversión del Instituto Cajal. Arbor 2007, CLXXXIII: 793-802. DOI: 10.3989/arbor.2007.i727.142.Peer-Reviewed Original Research