Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Bautista-Abad Á, García-Magro N, Pinto-Benito D, Cáceres-Pajuelo J, Alises C, Ganchala D, Lagunas N, Negredo P, García-Segura L, Arevalo M, Grassi D. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input. GeroScience 2024, 46: 6459-6472. PMID: 38954130, PMCID: PMC11493896, DOI: 10.1007/s11357-024-01268-z.Peer-Reviewed Original ResearchExpression of aromataseTrigeminal ganglionPain perceptionAndrogen receptorEstrogen receptorSensory neuronsDorsal root ganglia sensory neuronsIncreased expression of aromataseIncidence of trigeminal neuralgiaAged female animalsAssociated with sex-specific alterationsPresence of aromataseModulate pain perceptionRegulating pain perceptionSex-specific alterationsInvolvement of aromataseSex-specific mannerTrigeminal neuralgiaGene expressionFemale miceAromatase immunoreactivitySomatosensory inputEstrogen synthesisAR geneSex differences