Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex
Pinto-Benito D, Bautista-Abad A, Lagunas N, Ontiveros N, Ganchala D, Garcia-Segura L, Arevalo M, Grassi D. Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167532. PMID: 39366643, DOI: 10.1016/j.bbadis.2024.167532.Peer-Reviewed Original ResearchAging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Bautista-Abad Á, García-Magro N, Pinto-Benito D, Cáceres-Pajuelo J, Alises C, Ganchala D, Lagunas N, Negredo P, García-Segura L, Arevalo M, Grassi D. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input. GeroScience 2024, 46: 6459-6472. PMID: 38954130, PMCID: PMC11493896, DOI: 10.1007/s11357-024-01268-z.Peer-Reviewed Original ResearchExpression of aromataseTrigeminal ganglionPain perceptionAndrogen receptorEstrogen receptorSensory neuronsDorsal root ganglia sensory neuronsIncreased expression of aromataseIncidence of trigeminal neuralgiaAged female animalsAssociated with sex-specific alterationsPresence of aromataseModulate pain perceptionRegulating pain perceptionSex-specific alterationsInvolvement of aromataseSex-specific mannerTrigeminal neuralgiaGene expressionFemale miceAromatase immunoreactivitySomatosensory inputEstrogen synthesisAR geneSex differences