Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model
Cioffi L, Grassi D, Diviccaro S, Caruso D, Pinto-Benito D, Arevalo M, Garcia-Segura L, Melcangi R, Giatti S. Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 241: 106514. PMID: 38554982, DOI: 10.1016/j.jsbmb.2024.106514.Peer-Reviewed Original ResearchSex chromosome complementChromosome complementGenotype mouse modelNeuroactive steroid levelsNeuroactive steroidsMouse modelSteroid levelsSex chromosomesSRY geneSexual dimorphism levelsSex determinationContribution of sex chromosome complementTissue-specific actionsGonadsLiquid chromatography-tandem mass spectrometryGonadal hormonesChromatography-tandem mass spectrometryNeuroprotective actionSteroidsSexual featuresLevel regulationNervous systemSex-specificGenotypesComplement