Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2
Zhang H, Lu X, Garner D, Parween F, Singh S, Majumdar S, Weaver J, Stein S, Lesho P, Damcott C, Lutfi F, Petrick K, Rock P, Chertow D, Kelsall B, Murphy P, Dahiya S, Hardy N, Farber J. Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2. The Journal Of Immunology 2023, 210: 143.04-143.04. DOI: 10.4049/jimmunol.210.supp.143.04.Peer-Reviewed Original ResearchMAIT cellsSARS-CoV-2Chemokine receptorsCCR2-deficient miceHospitalized COVID-19 patientsCOVID-19 pathogenesisBlood pDCCOVID-19 patientsReporter miceAffecting disease severityCCR2 ligandsCCR2III interferonsBlood leukocytesType 1ChemokinesDisease severityIncreased mortalityBlood cellsReceptorsAbsolute numberLeukocyte extravasationLungTransendothelial migrationBloodExtravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines
Parween F, Singh S, Zhang H, Kathuria N, Farber J. Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines. The Journal Of Immunology 2023, 210: 79.07-79.07. DOI: 10.4049/jimmunol.210.supp.79.07.Peer-Reviewed Original ResearchEndothelial cellsTransendothelial migrationPro-inflammatory T cellsCCR2+ cellsMultiple chemokine receptorsHuman Th17 cellsImmune-mediated diseasesTransduced endothelial cellsBinding to endothelial cellsActivated endothelial cellsSites of inflammationActivity of receptorsTh17 signatureEndothelial cell surfaceTh17 cellsT cellsTh cellsChemokine receptorsGM-CSFCCR6Chemokine systemActivation of individual receptorsInhibition of transendothelial migrationApical sideTherapeutic benefit