2019
Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation
Singh T, Lu X, Singh S, Zhang H, Doucet M, Kominsky S, Farber J. Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation. The Journal Of Immunology 2019, 202: 183.21-183.21. DOI: 10.4049/jimmunol.202.supp.183.21.Peer-Reviewed Original ResearchIL-17-producingT cellsKnock-in miceIL-17Psoriasis-like skin inflammationGd T cellsExpression of CCL20Expression of IL17Hair folliclesCCR6 ligandIMQ treatmentPsoriatic dermatitisCCR6IL-22Skin inflammationReduce inflammationCCL20Day 4Treated skinInflammationMiceB-defensinsSuperficial epidermisKeratinocytesIMQ
2014
Blood monocytes expressing CCR6 and monocyte-derived dendritic cells in dermis and epidermis are critical for IL-23-induced psoriasis-like inflammation in mice (CAM5P.238)
Singh T, Zhang H, Farber J. Blood monocytes expressing CCR6 and monocyte-derived dendritic cells in dermis and epidermis are critical for IL-23-induced psoriasis-like inflammation in mice (CAM5P.238). The Journal Of Immunology 2014, 192: 180.9-180.9. DOI: 10.4049/jimmunol.192.supp.180.9.Peer-Reviewed Original ResearchCCR6-/- miceIL-23 injectionDendritic cellsPsoriasis-like inflammationIL-23Blood monocytesAccumulation of dendritic cellsMonocyte-derived dendritic cellsHuman studiesLangerin-DTR micePsoriasis-like pathologyExpression of CCR6Monocyte-derived cellsLangerin+ cellsInflamed skinMyeloid cellsNon-monocyticIL-22Injected i.Psoriatic skinCCR6InflammationMiceMouse skinMonocytes
2011
Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice (117.2)
Wan W, Lim J, Lionakis M, Rivollier A, McDermott D, Kelsall B, Farber J, Murphy P. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice (117.2). The Journal Of Immunology 2011, 186: 117.2-117.2. DOI: 10.4049/jimmunol.186.supp.117.2.Peer-Reviewed Original ResearchApoE-deficient miceCCR6-/- miceChemokine receptor CCR6Mice in vivoAtherosclerotic lesion areaApolipoprotein E-deficientApoE-/- miceReceptor CCR6Inflammatory monocytesLigand CCL20Monocyte functionCCR6Macrophage contentMonocyte levelsGenetic deletionPrimary monocytesLesional macrophagesWeeks of ageMouse monocytesMonocytesE deficiencyCCL20MiceMonocyte migrationCirculating blood