2017
Single-cell analysis of CCR6+ human Th cells reveals varying degrees of the type-17 phenotype, ranging from cells co-expressing to those fully suppressing opposing pathways
Singh S, Edara N, Zhang H, Chen J, Farber J. Single-cell analysis of CCR6+ human Th cells reveals varying degrees of the type-17 phenotype, ranging from cells co-expressing to those fully suppressing opposing pathways. The Journal Of Immunology 2017, 198: 150.14-150.14. DOI: 10.4049/jimmunol.198.supp.150.14.Peer-Reviewed Original ResearchType 17Co-expressionLineage-specific genesCo-expressed genesCells expressing various levelsTh cellsExpression of genesPattern of expressionSingle-cell analysisExpression of CCR6Opposing pathwaysMulti-lineage cellsGenesHuman Th cellsCells co-expressingLineagesDifferentiation in vivoCell sortingCCR6 expressionExpression levelsMemory populationIL-22IL-17A/FRT-PCRCCR6
2007
CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5)
Farber J, Song K, Zhang H, Rabin R, Hill B, Sereti I, Prussin C, Siegel R, Douek D, Roederer M. CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5). The Journal Of Immunology 2007, 178: s119-s119. DOI: 10.4049/jimmunol.178.supp.85.5.Peer-Reviewed Original ResearchMemory T cellsT cellsEffector capabilitiesExpression of chemokine receptors CCR5Memory CD4+ T cellsCD4+ memory T cellsCD4+ T cellsLong-lived memory cellsHuman memory CD4+ T cellsCCR2+ cellsCD4+ subsetHuman CD4+ memory T cellsChemokine receptor CCR5Antigen-responsive cellsChemokine receptor typeResistance to apoptosisSecrete high levelsCells co-expressingSusceptibility to apoptosisReduced proliferative potentialEffector cytokinesExcision circlesEnhanced migration potentialReceptor CCR5Peripheral blood