2023
Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines
Parween F, Singh S, Zhang H, Kathuria N, Farber J. Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines. The Journal Of Immunology 2023, 210: 79.07-79.07. DOI: 10.4049/jimmunol.210.supp.79.07.Peer-Reviewed Original ResearchEndothelial cellsTransendothelial migrationPro-inflammatory T cellsCCR2+ cellsMultiple chemokine receptorsHuman Th17 cellsImmune-mediated diseasesTransduced endothelial cellsBinding to endothelial cellsActivated endothelial cellsSites of inflammationActivity of receptorsTh17 signatureEndothelial cell surfaceTh17 cellsT cellsTh cellsChemokine receptorsGM-CSFCCR6Chemokine systemActivation of individual receptorsInhibition of transendothelial migrationApical sideTherapeutic benefit
2007
CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5)
Farber J, Song K, Zhang H, Rabin R, Hill B, Sereti I, Prussin C, Siegel R, Douek D, Roederer M. CCR2 identifies first responders among human CD4+ memory T cells: long-lived, apoptosis-resistant, antigen-responsive cells with enhanced migration potential, a low threshold for activation, and immediate effector capabilities (85.5). The Journal Of Immunology 2007, 178: s119-s119. DOI: 10.4049/jimmunol.178.supp.85.5.Peer-Reviewed Original ResearchMemory T cellsT cellsEffector capabilitiesExpression of chemokine receptors CCR5Memory CD4+ T cellsCD4+ memory T cellsCD4+ T cellsLong-lived memory cellsHuman memory CD4+ T cellsCCR2+ cellsCD4+ subsetHuman CD4+ memory T cellsChemokine receptor CCR5Antigen-responsive cellsChemokine receptor typeResistance to apoptosisSecrete high levelsCells co-expressingSusceptibility to apoptosisReduced proliferative potentialEffector cytokinesExcision circlesEnhanced migration potentialReceptor CCR5Peripheral blood