Loren Laine, MD
Professor of Medicine (Digestive Diseases)DownloadHi-Res Photo
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Chief, Section of Digestive Diseases, Internal Medicine
Chief, Section of Digestive Diseases
Medical Chief, Digestive Health, Yale New Haven Health
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), P.O. Box 208019
New Haven, CT 06520-8019
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Chief, Section of Digestive Diseases, Internal Medicine
Chief, Section of Digestive Diseases
Medical Chief, Digestive Health, Yale New Haven Health
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), P.O. Box 208019
New Haven, CT 06520-8019
United States
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Chief, Section of Digestive Diseases, Internal Medicine
Chief, Section of Digestive Diseases
Medical Chief, Digestive Health, Yale New Haven Health
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), P.O. Box 208019
New Haven, CT 06520-8019
United States
About
Titles
Professor of Medicine (Digestive Diseases)
Chief, Section of Digestive Diseases, Internal Medicine; Chief, Section of Digestive Diseases
Positions outside Yale
Medical Chief, Digestive Health, Yale New Haven Health
Appointments
Digestive Diseases
Section ChiefDualDigestive Diseases
ProfessorPrimary
Other Departments & Organizations
- Digestive Diseases
- Internal Medicine
- Liver Center
- Yale Medicine
Education & Training
- Fellowship
- UCSD (1984)
- Residency
- UCLA (1982)
- MD
- UCLA School of Medicine (1979)
Board Certifications
Gastroenterology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1985
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1982
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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Research
Overview
Medical Research Interests
Anti-Ulcer Agents; Dyspepsia; Fecal Microbiota Transplantation; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Helicobacter pylori; Peptic Ulcer
Research at a Glance
Yale Co-Authors
Frequent collaborators of Loren Laine's published research.
Publications Timeline
A big-picture view of Loren Laine's research output by year.
Research Interests
Research topics Loren Laine is interested in exploring.
Dennis Shung, MD, MHS, PhD
Thiruvengadam Muniraj, MD, FACG, FRCP
Allen Hsiao, MD, FAAP, FAMIA
Kenneth Hung, MD, MS
Priya Jamidar, FACG, FASGE, MBChB
Hamita Sachar, MD
401Publications
28,850Citations
Gastrointestinal Hemorrhage
Helicobacter pylori
Peptic Ulcer
Anti-Ulcer Agents
Dyspepsia
Gastroesophageal Reflux
Publications
2024
Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial
Chey W, Mégraud F, Laine L, Smith N, Leifke E, Hunt B, Howden C. Influence of patient characteristics on Helicobacter pylori eradication with Vonoprazan: A subgroup analysis of the pHalcon‐HP trial. JGH Open 2024, 8: e70044. PMID: 39554983, PMCID: PMC11567116, DOI: 10.1002/jgh3.70044.Peer-Reviewed Original ResearchS655 Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Non-Erosive Reflux Disease
Antunes C, Ghosh G, Katz P, Yadlapati R, Leifke E, Harris T, Graham H, Laine L. S655 Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Non-Erosive Reflux Disease. The American Journal Of Gastroenterology 2024, 119: s452-s453. DOI: 10.14309/01.ajg.0001031988.74205.82.Peer-Reviewed Original ResearchDetection of Gastrointestinal Bleeding with Large Language Models to Aid Quality Improvement and Appropriate Reimbursement
Zheng N, Keloth V, You K, Kats D, Li D, Deshpande O, Sachar H, Xu H, Laine L, Shung D. Detection of Gastrointestinal Bleeding with Large Language Models to Aid Quality Improvement and Appropriate Reimbursement. Gastroenterology 2024 PMID: 39304088, DOI: 10.1053/j.gastro.2024.09.014.Peer-Reviewed Original ResearchConceptsElectronic health recordsOvert gastrointestinal bleedingGastrointestinal bleedingRecurrent bleedingMachine learning modelsHealth recordsClinically relevant applicationsNursing notesLanguage modelAcute gastrointestinal bleedingQuality improvementLearning modelsDetection of gastrointestinal bleedingReimbursementIdentification of clinical conditionsSeparate hospitalsQuality measuresHospitalBleedingClinical conditionsPatient managementEarly identificationPatientsReimbursement codesCoding algorithmAGA Clinical Practice Update on Integrating Potassium-Competitive Acid Blockers Into Clinical Practice: Expert Review
Patel A, Laine L, Moayyedi P, Wu J. AGA Clinical Practice Update on Integrating Potassium-Competitive Acid Blockers Into Clinical Practice: Expert Review. Gastroenterology 2024, 167: 1228-1238. PMID: 39269391, DOI: 10.1053/j.gastro.2024.06.038.Peer-Reviewed Original ResearchConceptsPotassium-competitive acid blockerClinical Practice UpdateFirst-line therapyProton pump inhibitorsTwice-daily proton pump inhibitorBest Practice Advice statementsPractice advice statementsPeptic ulcer diseaseErosive esophagitisHeartburn symptomsAmerican Gastroenterological Association (AGA) Institute Clinical Practice UpdateClinical superiorityDouble-dose PPIsDouble-dose proton pump inhibitorsProphylaxis of peptic ulcer diseaseReflux diseaseStandard-dose PPIUlcer diseaseExpert reviewStandard procedures of GastroenterologyHigh-risk stigmataAcid inhibitionOn-demand therapyMaintenance of healingBleeding gastroduodenal ulcersValidation of an Electronic Health Record–Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding
Shung D, Chan C, You K, Nakamura S, Saarinen T, Zheng N, Simonov M, Li D, Tsay C, Kawamura Y, Shen M, Hsiao A, Sekhon J, Laine L. Validation of an Electronic Health Record–Based Machine Learning Model Compared With Clinical Risk Scores for Gastrointestinal Bleeding. Gastroenterology 2024, 167: 1198-1212. PMID: 38971198, PMCID: PMC11493512, DOI: 10.1053/j.gastro.2024.06.030.Peer-Reviewed Original ResearchAltmetricConceptsElectronic health recordsGlasgow-Blatchford scoreEmergency departmentVery-low-risk patientsRisk scoreOakland scoreMachine learning modelsStructured data fieldsClinical risk scoreGastrointestinal bleedingAll-cause mortalityHealth recordsLearning modelsManual data entrySecondary analysisRisk stratification scoresAssess proportionRed blood-cell transfusionPrimary outcomeProportion of patientsData entryOvert gastrointestinal bleedingPrimary analysisReceiver-operating-characteristic curveVery-low-riskAdoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis
Shung D, Li D, You K, Hung K, Laine L, Hughes M. Adoption of a gastroenterology hospitalist model and the impact on inpatient endoscopic practice volume: a controlled interrupted time-series analysis. IGIE 2024, 3: 329-332.e2. DOI: 10.1016/j.igie.2024.04.008.Peer-Reviewed Original ResearchConceptsControlled interrupted time series analysisHospitalist modelInterrupted time series analysisHigh-acuity hospitalAcademic health systemEndoscopy capacityInpatient coverageOutpatient providersProvider familiarityOutpatient careHealth systemWeekly volumeEndoscopy volumeHospital systemPractice volumeTime series analysisProcedure volumeGI patientsHospitalAcademic centersProvidersGastroenterologySeries analysisPotential benefitsEndoscopic proceduresComparison of LA Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial
Spechler S, Laine L, DeVault K, Nabulsi A, Hunt B, Katz P. Comparison of LA Grades of Erosive Esophagitis Scored by Local Investigators vs Central Adjudicators in a Clinical Trial. Clinical Gastroenterology And Hepatology 2024 PMID: 38777170, DOI: 10.1016/j.cgh.2024.05.007.Peer-Reviewed Original ResearchVonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial
Laine L, Spechler S, Yadlapati R, Schnoll-Sussman F, Smith N, Leifke E, Harris T, Hunt B, Fass R, Katz P. Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial. Clinical Gastroenterology And Hepatology 2024, 22: 2211-2220.e10. PMID: 38750866, DOI: 10.1016/j.cgh.2024.05.004.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNon-erosive reflux diseaseHeartburn-free daysErosive esophagitisReflux diseaseRandomized trialsActive-treatment extensionRandomized to placeboPotassium-competitive acid blockerPlacebo-controlled periodDays of therapyPercentage of subjectsPrimary endpointPercentage of daysHeartburn symptomsPlaceboVonoprazanAcid blockerNighttime heartburnDay 1Randomized subjectsDocumented efficacyStudy armsDay 2Adult subjectsExtension periodHuman-Algorithmic Interaction Using a Large Language Model-Augmented Artificial Intelligence Clinical Decision Support System
Rajashekar N, Shin Y, Pu Y, Chung S, You K, Giuffre M, Chan C, Saarinen T, Hsiao A, Sekhon J, Wong A, Evans L, Kizilcec R, Laine L, Mccall T, Shung D. Human-Algorithmic Interaction Using a Large Language Model-Augmented Artificial Intelligence Clinical Decision Support System. 2024, 1-20. DOI: 10.1145/3613904.3642024.Peer-Reviewed Original ResearchConceptsClinical decision support systemsHuman-computer interactionDecision support systemArtificial intelligenceAI-CDSSIntelligent clinical decision support systemSupport systemIntegration of artificial intelligenceHuman-algorithm interactionsEase-of-useLanguage modelHuman algorithmAI systemsSocio-technological challengesHealth-care providersMedical student participationQualitative themesClinical simulationClinical expertiseUpper gastrointestinal bleedingUsabilityBorderline decisionsLanguageClinical intuitionTrustMo1066 LARGE LANGUAGE MODEL-BASED SIMULATED PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING FOR MEDICAL EDUCATION – A PILOT STUDY WITH EMPATHGPT
Rajashekar N, Chan C, Laine L, Shung D. Mo1066 LARGE LANGUAGE MODEL-BASED SIMULATED PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING FOR MEDICAL EDUCATION – A PILOT STUDY WITH EMPATHGPT. Gastroenterology 2024, 166: s-933. DOI: 10.1016/s0016-5085(24)02628-3.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity Gastro Hep Advances
Advisory BoardsAdvisorDetailsAmerican Gastroenterological Association2021 - Presentactivity Alimentary Pharmacology & Therapeutics
Journal ServiceEditorial Board MemberDetails1994 - Presentactivity Digestive Disease Week
Professional OrganizationsChairDetails2020 - Presenthonor Elliot Weser Lectureship
National AwardUniversity of Texas, San AntonioDetails04/21/2021United Stateshonor Howard Spiro Teaching Award
Yale School of Medicine AwardDetails06/23/2020United States
Clinical Care
Board Certifications
Gastroenterology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1985
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1982
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Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), P.O. Box 208019
New Haven, CT 06520-8019
United States
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