Chromosomal Instability and Aging: Basic Science and Clinical Implications

edited by Fuki M. Hisama, M.D., HS ’92, assistant professor of neurology, Sherman M. Weissman, M.D., Sterling Professor of Genetics and professor of medicine, and George M. Martin, M.D.

Marcel Dekker Inc. (New York) 2003

Understanding the biological basis of aging is increasingly important as we anticipate the impact that a rapidly growing older population will have on the medical and social landscape. This book provides readers with background information on the biology of aging and the genetic alterations and epigenetic remodeling that occur with normative aging. It brings together expert reviews on the cellular and molecular bases of chromosomal instability and aging in human diseases and animal models, cellular senescence, telomeric regulations and oxidative stress.